17. NMA results for AEs (all risk groups combined).
Results of network meta‐analysis for outcome all‐cause AEs (grades 3 and 4). Treatments are ordered by P‐Score (descending). Only subnetworks with >1 designs. Upper triangle: direct estimate. Lower triangle: network estimate. Subnet 1 No. of studies: 10. No. of pairwise comparisons: 14. No. of treatments: 11. No. of designs: 10. Qtotal= 0.31, df = 2, P =0.85; Qwithin= 0.0, df = 0, P = n.a.; Qbetween=0.31, df = 2, P = 0.85; I² = 0.0%, Tau² = 0.0 Treatment Effects + 95%‐CIs (Risk ratios, random‐effects model): | ||||||||||
ATE | 0.63 [0.47, 0.83] | . | . | . | 0.58 [0.44, 0.76] | . | . | . | . | . |
0.64 [0.49, 0.83] | ATE+BEV | . | . | . | 0.89 [0.81, 0.97] | . | . | . | . | . |
0.70 [0.44, 1.11] | 1.09 [0.74, 1.61] | NIN | . | . | 0.82 [0.56, 1.20] | . | . | . | . | . |
0.59 [0.44, 0.78] | 0.92 [0.80, 1.06] | 0.84 [0.57, 1.26] | SOR | . | 0.99 [0.85, 1.14] | 0.92 [0.78, 1.09] | . | . | . | . |
0.57 [0.43, 0.75] | 0.89 [0.79, 1.01] | 0.82 [0.55, 1.21] | 0.97 [0.84, 1.12] | AVE+AXI | 1.00 [0.92, 1.08] | . | . | . | . | . |
0.57 [0.44, 0.74] | 0.89 [0.81, 0.97] | 0.82 [0.56, 1.20] | 0.97 [0.86, 1.08] | 1.00 [0.92, 1.08] | SUN | 0.98 [0.92, 1.05] | 0.96 [0.77, 1.21] | 0.94 [0.85, 1.03] | 0.87 [0.80, 0.95] | 0.86 [0.80, 0.94] |
0.56 [0.43, 0.73] | 0.87 [0.78, 0.97] | 0.80 [0.54, 1.18] | 0.95 [0.84, 1.06] | 0.98 [0.88, 1.09] | 0.98 [0.92, 1.05] | PAZ | . | . | . | . |
0.55 [0.39, 0.77] | 0.85 [0.67, 1.09] | 0.78 [0.50, 1.22] | 0.93 [0.72, 1.20] | 0.96 [0.75, 1.22] | 0.96 [0.77, 1.21] | 0.98 [0.77, 1.24] | CAB | . | . | . |
0.53 [0.40, 0.70] | 0.83 [0.73, 0.95] | 0.77 [0.52, 1.13] | 0.91 [0.78, 1.05] | 0.93 [0.82, 1.06] | 0.94 [0.85, 1.03] | 0.96 [0.85, 1.07] | 0.98 [0.76, 1.25] | NIV+CAB | . | . |
0.50 [0.38, 0.65] | 0.77 [0.69, 0.87] | 0.71 [0.48, 1.05] | 0.84 [0.73, 0.97] | 0.87 [0.77, 0.98] | 0.87 [0.80, 0.95] | 0.89 [0.80, 0.99] | 0.91 [0.71, 1.15] | 0.93 [0.82, 1.05] | LEN+PEM | 0.99 [0.93, 1.06] |
0.49 [0.37, 0.64] | 0.77 [0.68, 0.87] | 0.70 [0.48, 1.04] | 0.83 [0.73, 0.96] | 0.86 [0.76, 0.97] | 0.86 [0.80, 0.94] | 0.88 [0.79, 0.98] | 0.90 [0.71, 1.14] | 0.92 [0.81, 1.04] | 0.99 [0.93, 1.06] | LEN+EVE |