18. NMA results for Number of participants who discontinued study treatment due to an AE (all risk groups combined).

Results of network meta‐analysis for the outcome Number of participants who discontinued treatment due to an AE. Treatments are ordered by P‐Score (descending). Only subnetworks with >1 designs. Upper triangle: direct estimate. Lower triangle: network estimate. Subnet 1 No. of studies: 28. No. of pairwise comparisons: 34. No. of treatments: 24. No. of designs: 25. Qtotal= 18.14, df = 8, P = 0.020; Qwithin= 3.27, df = 3, P = 0.35; Qbetween= 14.87, df = 5, P = 0.011; I²=55.9%, Tau² = 0.1029 Treatment Effects + 95%‐CIs (Risk ratios, random‐effects model):

TIV

.

.

.

.

.

0.51 [0.24, 1.05]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.89 [0.28, 2.80]

AVE+AXI

.

.

.

0.57 [0.27, 1.20]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.67 [0.16, 2.79]

0.75 [0.19, 2.92]

ATE

.

.

0.76 [0.24, 2.36]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.53 [0.22, 1.32]

0.60 [0.24, 1.49]

0.80 [0.23, 2.80]

PAZ

.

1.24 [0.64, 2.43]

0.72 [0.35, 1.47]

.

.

.

0.69 [0.11, 4.31]

.

.

.

.

.

.

.

.

.

.

.

.

.

0.55 [0.16, 1.88]

0.61 [0.19, 1.94]

0.82 [0.19, 3.45]

1.02 [0.37, 2.85]

CAB

0.92 [0.38, 2.22]

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.50 [0.21, 1.20]

0.57 [0.27, 1.20]

0.76 [0.24, 2.36]

0.95 [0.56, 1.60]

0.92 [0.38, 2.22]

SUN

1.42 [0.80, 2.54]

1.02 [0.55, 1.87]

1.00 [0.28, 3.62]

0.89 [0.45, 1.79]

0.40 [0.02, 9.32]

0.86 [0.42, 1.74]

0.78 [0.39, 1.56]

.

.

0.71 [0.34, 1.47]

0.68 [0.33, 1.41]

0.51 [0.26, 1.01]

0.29 [0.09, 0.98]

.

0.41 [0.21, 0.82]

.

.

0.23 [0.07, 0.72]

0.51 [0.24, 1.05]

0.57 [0.24, 1.38]

0.76 [0.22, 2.61]

0.95 [0.56, 1.63]

0.93 [0.34, 2.53]

1.01 [0.63, 1.62]

SOR

.

.

.

.

.

.

0.72 [0.20, 2.58]

0.71 [0.28, 1.78]

.

.

.

0.75 [0.28, 1.96]

.

.

.

.

.

0.51 [0.18, 1.48]

0.58 [0.22, 1.51]

0.77 [0.21, 2.80]

0.96 [0.43, 2.15]

0.94 [0.32, 2.74]

1.02 [0.55, 1.87]

1.01 [0.47, 2.18]

EVE

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.50 [0.11, 2.38]

0.57 [0.13, 2.51]

0.76 [0.14, 4.21]

0.95 [0.24, 3.80]

0.92 [0.19, 4.39]

1.00 [0.28, 3.62]

0.99 [0.25, 3.90]

0.98 [0.24, 4.08]

NIN

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.45 [0.15, 1.37]

0.51 [0.18, 1.40]

0.67 [0.18, 2.56]

0.84 [0.35, 2.02]

0.82 [0.27, 2.53]

0.89 [0.45, 1.79]

0.89 [0.38, 2.05]

0.88 [0.35, 2.21]

0.89 [0.21, 3.85]

PEM+AXI

.

.

.

.

.

.

.

.

.

.

.

.

.

.

0.43 [0.13, 1.45]

0.49 [0.14, 1.65]

0.65 [0.15, 2.88]

0.81 [0.30, 2.19]

0.79 [0.21, 2.92]

0.86 [0.33, 2.25]

0.85 [0.32, 2.23]

0.84 [0.27, 2.64]

0.86 [0.17, 4.29]

0.96 [0.29, 3.16]

TEM

.

.

.

.

.

.

.

0.51 [0.22, 1.22]

.

.

.

0.36 [0.15, 0.83]

.

0.43 [0.14, 1.33]

0.48 [0.17, 1.36]

0.65 [0.17, 2.47]

0.81 [0.34, 1.96]

0.79 [0.26, 2.45]

0.86 [0.42, 1.74]

0.85 [0.36, 1.99]

0.84 [0.33, 2.15]

0.86 [0.20, 3.73]

0.96 [0.36, 2.59]

1.00 [0.30, 3.31]

NIV+CAB

.

.

.

.

.

.

.

.

.

.

.

.

0.39 [0.13, 1.19]

0.44 [0.16, 1.22]

0.59 [0.16, 2.23]

0.74 [0.31, 1.76]

0.72 [0.24, 2.20]

0.78 [0.39, 1.56]

0.77 [0.34, 1.78]

0.77 [0.31, 1.93]

0.78 [0.18, 3.36]

0.88 [0.33, 2.33]

0.91 [0.28, 2.98]

0.91 [0.34, 2.45]

IFN

.

.

.

.

.

.

.

.

.

.

.

0.36 [0.08, 1.59]

0.41 [0.09, 1.94]

0.55 [0.09, 3.23]

0.68 [0.17, 2.74]

0.67 [0.13, 3.39]

0.72 [0.18, 2.83]

0.72 [0.20, 2.58]

0.71 [0.16, 3.17]

0.72 [0.11, 4.72]

0.81 [0.17, 3.75]

0.84 [0.17, 4.18]

0.84 [0.18, 3.93]

0.92 [0.20, 4.27]

AXI

.

.

.

.

.

.

.

.

.

.

0.36 [0.11, 1.17]

0.41 [0.11, 1.45]

0.54 [0.12, 2.52]

0.68 [0.24, 1.96]

0.66 [0.17, 2.57]

0.72 [0.26, 2.01]

0.71 [0.28, 1.78]

0.71 [0.21, 2.34]

0.72 [0.14, 3.74]

0.80 [0.23, 2.79]

0.84 [0.22, 3.16]

0.84 [0.24, 2.93]

0.92 [0.27, 3.18]

0.99 [0.21, 4.81]

SOR+IFN

.

.

.

.

.

.

.

.

.

0.36 [0.11, 1.11]

0.40 [0.14, 1.14]

0.53 [0.14, 2.06]

0.67 [0.27, 1.64]

0.65 [0.21, 2.05]

0.71 [0.34, 1.47]

0.70 [0.29, 1.67]

0.69 [0.27, 1.80]

0.71 [0.16, 3.10]

0.79 [0.29, 2.17]

0.82 [0.25, 2.76]

0.83 [0.30, 2.28]

0.91 [0.33, 2.47]

0.98 [0.21, 4.61]

0.98 [0.28, 3.48]

LEN+PEM

0.96 [0.47, 1.95]

.

.

.

.

.

.

.

0.34 [0.11, 1.06]

0.38 [0.14, 1.09]

0.51 [0.13, 1.98]

0.64 [0.26, 1.57]

0.63 [0.20, 1.96]

0.68 [0.33, 1.41]

0.67 [0.28, 1.60]

0.67 [0.26, 1.72]

0.68 [0.16, 2.98]

0.76 [0.28, 2.08]

0.79 [0.24, 2.65]

0.79 [0.29, 2.19]

0.87 [0.32, 2.37]

0.94 [0.20, 4.42]

0.95 [0.27, 3.34]

0.96 [0.47, 1.95]

LEN+EVE

.

.

.

.

.

.

.

0.26 [0.09, 0.78]

0.29 [0.11, 0.79]

0.39 [0.10, 1.45]

0.48 [0.20, 1.14]

0.47 [0.16, 1.43]

0.51 [0.26, 1.01]

0.51 [0.22, 1.16]

0.50 [0.20, 1.25]

0.51 [0.12, 2.19]

0.57 [0.22, 1.51]

0.60 [0.18, 1.94]

0.60 [0.22, 1.59]

0.65 [0.25, 1.72]

0.71 [0.15, 3.26]

0.71 [0.21, 2.45]

0.72 [0.27, 1.96]

0.75 [0.28, 2.03]

NIV+IPI

.

.

.

.

.

.

0.24 [0.09, 0.68]

0.27 [0.10, 0.78]

0.36 [0.09, 1.42]

0.46 [0.20, 1.03]

0.45 [0.14, 1.41]

0.48 [0.23, 1.01]

0.48 [0.23, 0.99]

0.47 [0.18, 1.24]

0.48 [0.11, 2.13]

0.54 [0.20, 1.49]

0.56 [0.26, 1.23]

0.56 [0.20, 1.57]

0.62 [0.23, 1.70]

0.67 [0.15, 2.92]

0.67 [0.21, 2.16]

0.68 [0.24, 1.93]

0.71 [0.25, 2.01]

0.95 [0.35, 2.58]

IFN

.

.

0.81 [0.41, 1.62]

0.70 [0.33, 1.50]

0.77 [0.34, 1.74]

0.23 [0.06, 0.88]

0.25 [0.06, 1.00]

0.34 [0.07, 1.70]

0.42 [0.13, 1.40]

0.41 [0.10, 1.75]

0.45 [0.14, 1.41]

0.44 [0.14, 1.39]

0.44 [0.12, 1.61]

0.45 [0.08, 2.51]

0.50 [0.13, 1.91]

0.52 [0.16, 1.74]

0.52 [0.14, 2.01]

0.57 [0.15, 2.18]

0.62 [0.11, 3.46]

0.62 [0.14, 2.70]

0.63 [0.16, 2.46]

0.66 [0.17, 2.56]

0.88 [0.23, 3.32]

0.93 [0.37, 2.34]

EVE+BEV

.

0.87 [0.42, 1.80]

.

.

0.21 [0.07, 0.63]

0.23 [0.08, 0.64]

0.31 [0.08, 1.18]

0.39 [0.16, 0.93]

0.38 [0.12, 1.16]

0.41 [0.21, 0.82]

0.41 [0.18, 0.94]

0.40 [0.16, 1.02]

0.41 [0.10, 1.77]

0.46 [0.17, 1.23]

0.48 [0.15, 1.57]

0.48 [0.18, 1.29]

0.53 [0.20, 1.40]

0.57 [0.12, 2.63]

0.57 [0.16, 1.98]

0.58 [0.21, 1.59]

0.60 [0.22, 1.65]

0.80 [0.30, 2.12]

0.85 [0.31, 2.34]

0.92 [0.24, 3.50]

ATE+BEV

.

.

.

0.20 [0.06, 0.62]

0.22 [0.07, 0.70]

0.30 [0.07, 1.25]

0.37 [0.14, 0.96]

0.36 [0.10, 1.26]

0.39 [0.16, 0.95]

0.39 [0.16, 0.94]

0.38 [0.13, 1.12]

0.39 [0.08, 1.86]

0.44 [0.14, 1.35]

0.46 [0.17, 1.19]

0.46 [0.15, 1.42]

0.50 [0.16, 1.53]

0.54 [0.11, 2.57]

0.54 [0.15, 1.94]

0.55 [0.18, 1.74]

0.58 [0.18, 1.81]

0.76 [0.25, 2.33]

0.81 [0.46, 1.44]

0.87 [0.42, 1.80]

0.95 [0.31, 2.93]

IFN+BEV

.

0.84 [0.42, 1.68]

0.16 [0.05, 0.56]

0.18 [0.05, 0.65]

0.25 [0.05, 1.12]

0.31 [0.11, 0.88]

0.30 [0.08, 1.14]

0.33 [0.12, 0.89]

0.32 [0.12, 0.87]

0.32 [0.10, 1.04]

0.33 [0.06, 1.67]

0.36 [0.11, 1.24]

0.38 [0.17, 0.85]

0.38 [0.11, 1.30]

0.42 [0.12, 1.41]

0.45 [0.09, 2.29]

0.45 [0.12, 1.76]

0.46 [0.13, 1.59]

0.48 [0.14, 1.66]

0.64 [0.19, 2.14]

0.67 [0.32, 1.42]

0.73 [0.22, 2.38]

0.79 [0.23, 2.69]

0.83 [0.33, 2.13]

IFN+TEM

.

0.16 [0.05, 0.51]

0.19 [0.06, 0.58]

0.25 [0.06, 1.02]

0.31 [0.12, 0.78]

0.30 [0.09, 1.03]

0.33 [0.14, 0.77]

0.32 [0.14, 0.77]

0.32 [0.11, 0.92]

0.33 [0.07, 1.53]

0.37 [0.12, 1.10]

0.38 [0.15, 1.00]

0.38 [0.13, 1.16]

0.42 [0.14, 1.25]

0.45 [0.10, 2.12]

0.46 [0.13, 1.60]

0.46 [0.15, 1.42]

0.48 [0.16, 1.48]

0.64 [0.22, 1.90]

0.68 [0.37, 1.24]

0.73 [0.29, 1.85]

0.80 [0.27, 2.39]

0.84 [0.47, 1.49]

1.01 [0.39, 2.61]

TEM+BEV