Table I.
Baseline characteristics of the study population
| Characteristic | AD (N = 38,391) | Non-AD (N = 2,643,602) | p-value |
|---|---|---|---|
| Age, years, mean ± SD | 55.63 ± 10.81 | 54.09 ± 10.31 | < 0.0001 |
| ≥ 65 years, n (%) | 8,925 (23.25) | 475,663 (17.99) | < 0.0001 |
| Sex, n (%) | < 0.0001 | ||
| Male | 17,375 (45.26) | 1,334,236 (50.47) | |
| Female | 21,016 (54.74) | 1,309,366 (49.53) | |
| Smoking, n (%) | < 0.0001 | ||
| Non-smoker | 25,730 (67.02) | 1,671,871 (63.24) | |
| Ex-smoker | 6,046 (15.75) | 412,135 (15.59) | |
| Current smoker | 6,615 (17.23) | 559,596 (21.17) | |
| Drinking status, n (%) | < 0.0001 | ||
| Abstinence | 24,507 (63.84) | 1,538,467 (58.2) | |
| Ex-drinker | 11,680 (30.42) | 909,856 (34.42) | |
| Current drinker | 2,204(5.74) | 195,279 (7.39) | |
| Regular exercise, yes, n (%) | 7,901(20.58) | 530,685 (20.07) | 0.014 |
| Body mass index < 25 kg/m2, yes, n (%) | 24,712 (64.36) | 1,719,425 (65.04) | 0.0183 |
| Diabetes mellitus, yes, n (%) | 4,987 (12.99) | 306,784 (11.6) | < 0.0001 |
| Hypertension, yes, n (%) | 14,980 (39.02) | 927,041 (35.07) | < 0.0001 |
| Dyslipidaemia, yes, n (%) | 10,329 (26.9) | 603,396 (22.82) | < 0.0001 |
| Systolic blood pressure, mm Hg, mean ± SD | 123.82 ± 15.26 | 124.19 ± 15.52 | < 0.0001 |
| Diastolic blood pressure, mmHg, mean ± SD | 76.73 ± 10.04 | 77.19 ± 10.24 | < 0.0001 |
| Glucose, mg/dL, mean ± SD | 99.63 ± 25.49 | 100.04 ± 25.93 | 0.0021 |
| Total cholesterol, mg/dL, mean ± SD | 199.89 ± 44.37 | 199.37 ± 42.52 | 0.018 |
| High-density lipoprotein cholesterol, mg/dL, mean ± SD | 56.73 ± 37.03 | 56.1 ± 33.74 | 0.0003 |
| Low-density lipoprotein cholesterol, mg/dL, mean ± SD | 119.87 ± 73.27 | 119.07 ± 84.1 | 0.0645 |
| Triglyceride, mg/dL, geometric mean (95% confidence interval | 118.53 (117.87–119.19) | 117.91 (117.83–117.99) | 0.0709 |
SD: standard deviation; AD: atopic dermatitis.