Table II.
Risk of dementia according to the presence of atopic dermatitis (AD)
| Number of events | IR | HR (95% CI) |
||||
|---|---|---|---|---|---|---|
| Non-adjusted | Model 1 | Model 2 | Model 3 | |||
| All-cause dementia | ||||||
| Non-AD | 107,727 | 5.045 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| AD | 2,058 | 6.699 | 1.331 (1.274–1.390) | 1.09 (1.044–1.139) | 1.086 (1.040–1.135) | 1.072 (1.026–1.120) |
| p-value | < 0.0001 | 0.0001 | 0.0002 | 0.0017 | ||
| Alzheimer’s disease | ||||||
| Non-AD | 86,053 | 4.030 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| AD | 1,609 | 5.237 | 1.302 (1.240–1.368) | 1.066(1.015–1.12) | 1.063 (1.012–1.117) | 1.051 (1–1.104) |
| p-value | < 0.0001 | 0.0111 | 0.0153 | 0.0485 | ||
| Vascular dementia | ||||||
| Non-AD | 13,507 | 0.632 | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) |
| AD | 267 | 0.869 | 1.377 (1.220–1.555) | 1.145 (1.014–1.292) | 1.135 (1.005–1.281) | 1.111 (0.984–1.254) |
| p-value | < 0.0001 | 0.0286 | 0.041 | 0.0896 | ||
Cox regression models were used to assess the risks of all-cause dementia, Alzheimer’s disease, and vascular dementia in patients with atopic dermatitis. Incidence rate is per 1,000 person-years. Model 1 was adjusted for age and sex. Model 2 was adjusted for age, sex, body mass index, smoking, drinking, regular exercise, hypertension, diabetes mellitus, and dyslipidaemia. Model 3 was adjusted for age, sex, body mass index, smoking, drinking, regular exercise, hypertension, diabetes mellitus, dyslipidaemia, stroke, and ischaemic heart disease.
CI: confidence interval; HR: hazard ratio; IR: incidence rate.