Table 1.
Detailed information on GWASs of exposures and outcome.
| Exposure or outcome | IVs | IVs available | Cochran Q | Q–P value | Intercept | P for intercept | Outliers | Sample size | Ancestry | Units | SNPs | F |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exposure | ||||||||||||
| Educational level | 261 | 253/238 | 249 | .267 | −0.004 | 0.635 | 0 | 458,079 | European | SD | 9,851,867 | 10 |
| HPW | 25 | 22/21 | 14 | .790 | 0.019 | 0.626 | 0 | 263,615 | European | SD | 9,851,867 | 29 |
| BMI | 458 | 442/415 | 453 | .087 | 0.001 | 0.849 | 0 | 461,460 | European | SD | 9,851,867 | 61 |
| WC | 374 | 360/339 | 333 | .558 | −0.004 | 0.334 | 0 | 462,166 | European | SD | 9,851,867 | 44 |
| MD | 50 | 46/44 | 34 | .789 | 0.001 | 0.960 | 0 | 500,199 | European | NA | NA | 183 |
| Outcome | ||||||||||||
| Cervicalgia | - | - | - | - | - | - | - | 167,956 | European | Odds ratio | 16,380,284 | - |
| Exposure | ||||||||||||
| Educational level | 261 | 253/233 | 251 | .180 | 0.001 | 0.736 | 0 | 458,079 | European | SD | 9,851,867 | 10 |
| HPW | 25 | 22/21 | 30 | .057 | 0.021 | 0.396 | 0 | 263,615 | European | SD | 9,851,867 | 28 |
| BMI | 458 | 442/402 | 445 | .058 | 0.001 | 0.861 | 0 | 461,460 | European | SD | 9,851,867 | 60 |
| WC | 374 | 360/328 | 355 | .126 | −0.002 | 0.341 | 0 | 462,166 | European | SD | 9,851,867 | 43 |
| MD | 50 | 45/40 | 50 | .096 | 0.026 | 0.119 | 0 | 500,199 | European | NA | NA | 173 |
| LSB | 113 | 108/99 | 115 | .105 | −0.016 | 0.060 | 0 | 437,887 | European | SD | 9,851,867 | 22 |
| Smoking initiation | 93 | 90/79 | 94 | .093 | −0.009 | 0.325 | 0 | 607,291 | European | NA | 11,802,365 | 161 |
| AIF | 99 | 97/92 | 113 | .051 | −0.002 | 0.739 | 0 | 462,346 | European | SD | 9,851,867 | 117 |
| Outcome | ||||||||||||
| LBP | - | - | - | - | - | - | - | 177,860 | European | Odds ratio | 16,380,287 | - |
AIF = alcohol intake frequency, BMI = body mass index, GWAS = genome-wide association study, HPW = heavy physical work, IVs = instrumental variables, LBP = low back pain, LSB = leisure sedentary behavior, MD = major depression, SD = standard deviation, SNPs = single-nucleotide polymorphisms, WC = waist circumference.