FIGURE 2.
pPRL (pituitary prolactin) is mainly synthesized and secreted by the lactotroph cells of the anterior pituitary, and this process is mainly regulated by dopamine and thyroid stimulating hormone releasing hormone (TRH) released in the hypothalamus. pPRL exerts a negative feedback effect on its own secretion by affecting dopamine secretion in the hypothalamous or direct action on lactotroph cells. PRL is also produced by autocrine and paracrine cells in numerous extrapituitary tissues (ePRL), such as immune cells and vascular endothelial cells. 85 Promotion is indicated by a solid line with arrow, and the other line indicates inhibition.