TABLE 2.

Values of pharmacokinetic parameters obtained with infection models^a

Regimen	Peak concn (μg/ml)	Trough concn (μg/ml)	Alpha half-life (h)	Beta half-life (h)	AUC0–24 (μg · h/ml)
Vancomycin, 1 g every 12 h	35.0  ± 4.8	8.4  ± 1.8	NDb	6.2  ± 1.0	464  ± 52
Vancomycin, 1.125 g every 12 h	52.7  ± 3.0	15.5  ± 2.1	ND	6.2  ± 0.3	678  ± 59
Vancomycin, 1.25 g every 12 h	59.0  ± 5.7	17.1  ± 2.0	ND	6.7  ± 1.0	804  ± 32
Vancomycin, 1.5 g every 12 h	66.7  ± 4.6	18.6  ± 1.1	ND	6.3  ± 0.6	885  ± 42
LY333328, low dose	57.1  ± 9.9	1.2  ± 0.3	1.8  ± 0.2	9.1  ± 1.6	192  ± 31
LY333328, high dose	97.2  ± 10.9	11.6  ± 2.0	1.4  ± 0.2	19.5  ± 2.8	612  ± 80
Gentamicin every 12 h	8.0  ± 0.8	0.7  ± 0.2	ND	3.1  ± 0.4	65.1  ± 6.9

^aValues are means ± standard deviations. 

^bND, not determined.