TABLE 2.
Regimen | Peak concn (μg/ml) | Trough concn (μg/ml) | Alpha half-life (h) | Beta half-life (h) | AUC0–24 (μg · h/ml) |
---|---|---|---|---|---|
Vancomycin, 1 g every 12 h | 35.0 ± 4.8 | 8.4 ± 1.8 | NDb | 6.2 ± 1.0 | 464 ± 52 |
Vancomycin, 1.125 g every 12 h | 52.7 ± 3.0 | 15.5 ± 2.1 | ND | 6.2 ± 0.3 | 678 ± 59 |
Vancomycin, 1.25 g every 12 h | 59.0 ± 5.7 | 17.1 ± 2.0 | ND | 6.7 ± 1.0 | 804 ± 32 |
Vancomycin, 1.5 g every 12 h | 66.7 ± 4.6 | 18.6 ± 1.1 | ND | 6.3 ± 0.6 | 885 ± 42 |
LY333328, low dose | 57.1 ± 9.9 | 1.2 ± 0.3 | 1.8 ± 0.2 | 9.1 ± 1.6 | 192 ± 31 |
LY333328, high dose | 97.2 ± 10.9 | 11.6 ± 2.0 | 1.4 ± 0.2 | 19.5 ± 2.8 | 612 ± 80 |
Gentamicin every 12 h | 8.0 ± 0.8 | 0.7 ± 0.2 | ND | 3.1 ± 0.4 | 65.1 ± 6.9 |
Values are means ± standard deviations.
ND, not determined.