Table 2. Reproduction and replication t-test results comparing controls and those with anhedonia across ABCD study samples.
| ABCD 1.0 Sample (n = 2437) | ABCD 4.0 (excluding 1.0) Sample (n = 6456) | Full ABCD 4.0 Sample (n = 8866) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rsfMRI Connectivity | Cohen’s d (95% CI) | p | p.adj | lnBF | Cohen’s d (95% CI) | p | p.adj | lnBF | Cohen’s d (95% CI) | p | p.adj | lnBF |
| CinguloOpercular-BrainStem | 0.203 (0.058, 0.347) | 0.006 | 0.167 | 1.204 | 0.096 (0.011, 0.181) | 0.028 | 0.144 | -0.611 | 0.125 (0.052, 0.199) | 0.001 | 0.013 | 2.436 |
| CinguloParietal-BrainStem | -0.258 (-0.404, -0.112) | 0.001 | 0.045 | 3.366 | -0.019 (-0.104, 0.067) | 0.672 | 0.878 | -2.924 | -0.032 (-0.106, 0.041) | 0.389 | 0.591 | -2.793 |
| CinguloParietal-RightPallidum | 0.222 (0.078, 0.366) | 0.003 | 0.086 | 1.974 | 0.112 (0.027, 0.197) | 0.010 | 0.096 | 0.262 | 0.097 (0.023, 0.17) | 0.010 | 0.062 | 0.151 |
| Default-DorsalAttention | -0.253 (-0.397, -0.109) | 0.001 | 0.045 | 3.290 | -0.071 (-0.156, 0.015) | 0.104 | 0.335 | -1.709 | -0.134 (-0.207, -0.061) | 0.000 | 0.007 | 3.284 |
| DorsalAttention-LeftHippocampus | -0.291 (-0.436, -0.146) | 0.000 | 0.027 | 5.060 | -0.037 (-0.123, 0.048) | 0.391 | 0.650 | -2.651 | -0.08 (-0.154, -0.007) | 0.032 | 0.124 | -0.884 |
| RetrosplenialTemporal-RightCerebellumCortex | 0.226 (0.082, 0.369) | 0.002 | 0.079 | 2.151 | 0.119 (0.033, 0.204) | 0.007 | 0.082 | 0.640 | 0.132 (0.058, 0.205) | 0.000 | 0.009 | 2.993 |
| Salience-LeftVentraldc | -0.242 (-0.386, -0.098) | 0.001 | 0.051 | 2.809 | -0.084 (-0.169, 0.001) | 0.053 | 0.222 | -1.159 | -0.121 (-0.195, -0.048) | 0.001 | 0.015 | 2.070 |
| SensorimotorHand-BrainStem | 0.247 (0.1, 0.393) | 0.001 | 0.051 | 2.854 | 0.096 (0.011, 0.181) | 0.027 | 0.144 | -0.595 | 0.122 (0.049, 0.195) | 0.001 | 0.015 | 2.136 |
| SensorimotorHand-RightHippocampus | 0.22 (0.074, 0.365) | 0.003 | 0.094 | 1.809 | -0.01 (-0.095, 0.075) | 0.820 | 0.940 | -2.992 | 0.038 (-0.035, 0.112) | 0.303 | 0.509 | -2.642 |
| Within CinguloOpercular | 0.229 (0.086, 0.372) | 0.002 | 0.074 | 2.323 | 0.129 (0.044, 0.214) | 0.003 | 0.048 | 1.350 | 0.144 (0.071, 0.217) | 0.000 | 0.004 | 4.254 |
| Within RetrosplenialTemporal | 0.266 (0.123, 0.409) | 0.000 | 0.042 | 3.989 | 0.034 (-0.051, 0.119) | 0.434 | 0.692 | -2.715 | 0.086 (0.013, 0.159) | 0.021 | 0.093 | -0.533 |
Student’s and Bayes Factor T-tests were performed to compare controls with those with anhedonia. Student’s t-statistic nominal p-values (p), conservative Benjamini-Hochberg adjusted p-values (p.adj) for 306 comparisons, and natural logarithms of Bayes Factors (lnBF) are reported. lnBF values greater than 1.1 were considered statistically significant. Note that the sum of the participants from the ABCD 1.0 and ABCD 4.0 (excluding) 1.0 samples exceeds the number of participants from the full ABCD 4.0 sample due to additional participants from the ABCD 1.0 sample being excluded from the full ABCD 4.0 sample during the quality control (QC) steps. Differences between processing pipelines between the data releases may account for these discrepancies in QC measures.