Table 4. Biologic abnormalities recorded at admission and during hospitalization.
| Total | Early AV | Delayed AV | p | ||||
|---|---|---|---|---|---|---|---|
| Parameter | Nb | Result | Nb | Result | Nb | Result | |
| Rhabdomyolysis | 119 | 15 (12.6%) | 45 | 3 (6.7%) | 74 | 12 (16.2%) | 0.161 |
| Hemolysis | 119 | 44 (37%) | 45 | 16 (35.6%) | 74 | 28 (37.8%) | 0.803 |
| Time from SB to resolved hemolysis | 34 | 24:44 (20:15–37:07) | 13 | 21:00 (16:20–25:24) | 21 | 27:00 (24:00–46:00) | 0.008 |
| Presence of schistocytes | 31 | 3 (9.7%) | 13 | 1 (7.7%) | 18 | 2 (11.1%) | 1.000 |
| Defibrinogenation | 119 | 119 (100%) | 45 | 45 (100%) | 74 | 74 (100%) | - |
| Time from SB to normal fibrinogen | 112 | 26:55 (22:00–36:02) | 45 | 23:27 (20:00–27:10) | 67 | 31:23 (24:00–45:05) | 0.000 |
| Time from AV to normal fibrinogen | 112 | 15:52 (11:58–21:55) | 45 | 18:00 (14:26–21:54) | 67 | 14:10 (10:16–22:10) | 0.069 |
| Fibrinogen dosage>0.35 g/L on admission | 118 | 33 (28%) | 45 | 7 (15.6%) | 73 | 26 (35.6%) | 0.018 |
| INR>2 | 119 | 105 (88.2%) | 45 | 43 (95.6%) | 74 | 62 (83.8%) | 0.053 |
| Time from SB to normal INR | 98 | 23:17 (17:31–34:37) | 41 | 18:30 (16:14–30:30) | 57 | 25:30 (19:51–41:00) | 0.006 |
| Time from AV to normal INR | 98 | 12:00 (09:17–17:24) | 41 | 12:10 (11:14–17:07) | 57 | 11:58 (07:00–17:30) | 0.137 |
| aPTT>1.5 | 119 | 71 (59.7%) | 45 | 34 (75.6%) | 74 | 37 (50%) | 0.006 |
| Time from SB to normal aPTT | 70 | 17:24 (13:26–24:00) | 33 | 13:45 (11:00–17:18) | 37 | 21:37 (16:30–29:20) | 0,000 |
| Time from AV to normal aPTT | 70 | 08:45 (05:31–11:55) | 33 | 09:21 (05:40–11:43) | 37 | 08:10 (05:10–12:20) | 0.888 |
| Thrombocytopenia | 119 | 31 (26.1%) | 45 | 11 (24.4%) | 74 | 20 (27%) | 0.756 |
| Time from SB to normal platelet count | 24 | 66:30 (31:37–122:51) | 10 | 55:45 (34:15–115:08) | 14 | 68:05 (30:32–112:02) | 0.861 |
| Time from AV to normal platelet count | 24 | 57:34 (17:50–111:51) | 10 | 47:00 (19:57–110:32) | 14 | 57:34 (12:22–96:45) | 0.558 |
| Abnormal Factor II | 107 | 53 (49.5%) | 45 | 23 (51.1%) | 62 | 30 (48.4%) | 0.781 |
| Time from SB to normal FII | 29 | 32:35 (17:40–41:50) | 13 | 20:15 (16:10–27:00) | 16 | 37:35 (32:28–48:45) | 0.010 |
| Time from AV to normal FII | 29 | 17:15 (09:30–25:10) | 13 | 14:40 (09:30–20:13) | 16 | 20:45 (13:15–25:50) | 0.211 |
| Abnormal Factor V | 108 | 66 (61.1%) | 45 | 33 (73.3%) | 63 | 33 (52.4%) | 0.028 |
| Time from SB to normal FV | 47 | 24:50 (17:50–35:10) | 24 | 18:28 (15:20–25:15) | 23 | 31:30 (24:45–38:20) | 0.000 |
| Time from AV to normal FV | 47 | 14:00 (09:55–21:00) | 24 | 12:05 (09:19–16:15) | 23 | 17:30 (11:25–22:30) | 0.154 |
| Abnormal Factor VII | 107 | 36 (33.6%) | 45 | 13 (28.9%) | 62 | 23 (37.1%) | 0.375 |
| Time from SB to normal FVII | 13 | 28:00 (18:00–44:50) | 4 | 41:15 (22:59–62:25) | 9 | 28:00 (18:00–41:50) | 0.643 |
| Time from AV to normal FVII | 13 | 15:20 (08:30–26:50) | 4 | 30:43 (08:27–54:10) | 9 | 15:20 (08:30–16:30) | 0.355 |
| Abnormal Factor X | 104 | 27 (26%) | 44 | 11 (25%) | 60 | 16 (26.7%) | 0.848 |
| Time from SB to normal FX | 11 | 32:10 (18:30–35:10) | 4 | 21:28 (11:49–33:35) | 7 | 33:40 (26:05–35:10) | 0.345 |
| Time from AV to normal FX | 11 | 19:30 (09:13–24:20) | 4 | 16:58 (08:19–27:46) | 7 | 19:30 (10:03–22:25) | 0.850 |
Nb: the number of cases in whom the parameter was analyzed, Values are expressed as number and percentages or median and interquartile range, SB: snakebite, AV: antivenom, INR: International Normalized Ratio, aPTT: activated partial thromboplastin time