Skip to main content
. 2023 Apr 24;19(4):e1011022. doi: 10.1371/journal.pcbi.1011022

Fig 6. MultiCens on multi-brain-region networks in disease.

Fig 6

Study of changes in MultiCens Query-set centrality based gene rankings of four-layer networks of control and Alzheimer affected population. We rank genes of frontal pole (FP), superior temporal gyrus (STG) and inferior frontal gyrus (IFG) using MultiCens centralities calculated using a query-set of synaptic signaling genes in parahippocampal gyrus (PHG). (A) Bar-plot showing region-wise shift of centrality scores of the three regions. (B) Reactome pathways and Gene Ontology-based process (GO-BP) enrichment analysis of each region in control and AD state. Color map represents the normalized enrichment score from WebGestalt. The highlighted boxes pass the 0.01 FDR cut-off. If centrality-based gene rankings of a region do not pass the 0.05 FDR cut off for an enrichment, we set the corresponding normalized enrichment score to 0.