Table 2. Hazard ratios (HR) and corresponding 95% confidence intervals (CI) associated with polygenic risk score quintiles (Q) compared to the population median, using the Cox proportional hazards model and censored at 20 years after recruitment.

Individuals were categorised into cancer-specific quintiles based on their cancer-specific polygenic risk score (PRS). All models were adjusted for age at recruitment.

Cancer site – gender	Q1	Q2	Q3	Q4	Q5
Breast – female
Number of cases	55	73	86	107	145
HR (95% CI)	0.61 (0.44–0.86)	0.80 (0.59–1.09)	1.00 (Referent)	1.25 (0.94–1.66)	1.64 (1.26–2.14)
Prostate – male
Number of cases	15	31	55	59	129
HR (95% CI)	0.28 (0.16–0.50)	0.57 (0.37–0.88)	1.00 (Referent)	1.11 (0.77–1.60)	2.52 (1.84–3.46)
Colorectal – female
Number of cases	47	43	53	66	101
HR (95% CI)	0.84 (0.57–1.25)	0.80 (0.53–1.20)	1.00 (Referent)	1.27 (0.88–1.82)	1.91 (1.37–2.67)
Colorectal – male
Number of cases	36	70	71	87	114
HR (95% CI)	0.51 (0.34–0.77)	1.00 (0.72–1.39)	1.00 (Referent)	1.29 (0.94–1.76)	1.67 (1.24–2.25)
Lung – female
Number of cases	25	26	41	36	40
HR (95% CI)	0.56 (0.34–0.92)	0.55 (0.34–0.91)	1.00 (Referent)	0.89 (0.57–1.39)	0.95 (0.61–1.47)
Lung – male
Number of cases	51	58	68	80	103
HR (95% CI)	0.72 (0.50–1.04)	0.79 (0.56–1.13)	1.00 (Referent)	1.14 (0.82–1.57)	1.46 (1.07–1.98)