(A) No significant differences were observed between tenecteplase (pooled analysis of 0.25 and 0.40 mg/kg dosing) and alteplase (acOR 1.48 95% CI 0.44–5.00), adjusting for baseline NIH Stroke Scale, age, time from symptom onset to arterial puncture, and study. (B) No significant differences were observed between tenecteplase (pooled analysis of 0.25 mg/kg and 0.40 mg/kg dosing) and alteplase (acOR 1.49 95% CI 0.85–2.60), adjusting for baseline NIH Stroke Scale, age, time from symptom onset to arterial puncture, and study. acOR = adjusted common odds radio; mRS = modified Rankin scale.