Fig. 10.

CBP/p300 and PCAF/GCN5 inhibitors. a Crystal structures of GEN-781 bound to CBP (PDB ID: 5W0E). b Crystal structures of GEN-781 bound to BRD4 BD1 (PDB ID: 5VZS). c Chemical structures of CBP/p300 inhibitors 149 − 165. d Chemical structures of PCAF/GCN5 inhibitors 166 − 170. Key residues are highlighted with gray sticks, and ligands are blue. Hydrogen bonds are shown in red dashed lines. The activity test methods are bolded