Fig. 6.

BD2-selective inhibitors. a Crystal structures of RVX-208 bound to BRD4 BD1(PDB ID: 4MR4). b Crystal structures of RVX-208 bound to BRD2 BD2 (PDB ID: 4MR6). c Crystal structures of ABBV-744 bound to BRD2 BD1 (PDB ID: 6ONY). d Crystal structures of ABBV-744 bound to BRD2 BD2 (PDB ID: 6E6J). e Chemical structures of BD2-selective inhibitors 82 − 103. Key residues are highlighted with gray sticks, and ligands are blue. Hydrogen bonds are shown in red dashed lines. The activity test methods are bolded and the selectivity is labeled