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. 2023 Apr 3;8(5):860–874. doi: 10.1038/s41564-023-01352-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — (a) Two-dimensional projections of single-cell transcriptomes using UMAP of blood cells from prime-boost experiment. Cells are colored by cell types as annotated based on known marker genes. (b, d) Numbers of cellular components per ml blood for the prime-boost experiment. (c) Percentage of blood cellular components for the prime-boost experiment. (b – d) One-way ANOVA and Dunnett’s multiple comparisons test against mock-mock group per cell type are shown. Mean ± SEM, symbols represent individual hamster. n_{sCPD9 + sCPD9} = 3, n_{mRNA + sCPD9} = 3, n_{mRNA + mRNA} = 3, n_{Ad2 + Ad2} = 3, n_{mock + mock} = 4 individual hamsters as symbols. ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.

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