Extended Data Fig. 10. Increased chromatin accessibility for TF binding at Casp1 locus in Sensitized USCs, related to Figs. 3 and 5.

(A) Differences in chromatin accessibility, DNA methylation, and histone modifications, H3K4Me3 and H3K27Ac, in different USCs were assessed by ATAC-seq, whole genome bisulfite sequencing (WGBS), and CUT&RUN. Relative DNA methylation, chromatin accessibility, and histone modifications at the Casp1 promoter site comparing Naïve, Resolved and Sensitized USCs are shown as a heatmap by displaying the normalized signal using read coverage and fraction of reads under consensus peaks. (B) Potential TF binding sites near Casp1 promoter are visualized on the epigenome browser map.