Fig. 2. The viral gut microbiota differs between AN cases and controls.
a,b, Box plot (line, median; box, IQR; whiskers, 1.5× IQR) of changes in Chao1 richness (a) and Shannon diversity (b) of the viral gut microbiota between AN (n = 77) and HC (n = 70) at viral species level. Significance was examined by two-sided Wilcoxon rank-sum test (a,b). c, Cliff’s delta values of contrasted gut viral species between AN and HC with Padj < 0.05 by Benjamini-Hochberg correction (given next to the viral annotation). The differential species were identified by metadeconfoundR pipeline where impacts of cofactors including age, smoking and multiple drug intake were deconfounded. d, Difference in number of trans-kingdom ecologic correlations between the viral and bacterial gut microbiota in AN (n = 77) compared to HC (n = 70), and between two AN subtypes (AN-RS n = 56, AN-BP n = 21) using the SparCC algorithm.