Fig. 3. Predicted functional potentials of the bacterial gut microbiome in AN cases and healthy control participants.
a, Cliff’s delta effect size of contrasted functional modules between AN (n = 77) and HC (n = 70) using the metadeconfoundR pipeline where interferences from covariates including age, BMI, smoking and multiple drug intake were corrected. Gold bars, functional modules more abundant in AN; blue bars, functional modules more abundant in HC. For each contrasted module, P value after Benjamini-Hochberg correction is given next to the module annotation. b, Heat map of the associations between clinical variables and functional potentials of gut bacteriome by linear regression model where impacts of covariates including age, smoking and multiple drug intake were deconfounded. + indicates P < 0.05 by Benjamini-Hochberg correction (see for exact P values).