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. Author manuscript; available in PMC: 2023 Nov 1.
Published in final edited form as: Nat Chem Biol. 2023 Jan 26;19(5):633–640. doi: 10.1038/s41589-022-01246-6

Fig. 2. AnkA and homologs from fungi are cyclo-arginine-Xaa-dipeptide synthases (CRDPS).

Fig. 2.

MAFFT phylogenetic tree of select AnkA homologs from sequenced fungal genomes. Six additional gene clusters encoding the analogs are shown on the right. Genes encoding AnkA homologs (AvaA, AnoA, PthA, AteA, AmaA and EshA) are shown in red, while genes encoding putative tailoring enzymes are shown in green. The % identity and % coverage of these homologs to AnkA are shown in parenthesis. Structures of arginine-containing cyclodipeptides synthesized by expression of the CRDPS are shown on the right.