Table 2.
A Comparison of PSA Levels in the Study and Control Groups, and Subgroups Analyses
| Number of individuals | Age, years, median (IQR) | Baseline PSA, ng/dL, median (IQR) | Days between PSA tests, median days (IQR) | PSA change, ng/dL median (IQR) | P value for PSA change* | ||
|---|---|---|---|---|---|---|---|
| Overall | Study group | 6,733 | 64.6 (59, 69) | 1.09 (0.6, 2) | 440 (323, 583) | 0.04 (-0.1, 0.3) | <.001 |
| Control group | 16,286 | 65.2 (60, 70) | 1.13 (0.6, 2) | 469 (405, 564) | 0.02 (-0.1, 0.2) | ||
| Vaccination vs. infection | 1 vaccine dose | 659 | 64.2 (58, 70) | 1.07 (0.6, 2) | 420 (280, 578) | 0.03 (-0.12, 0.28) | .6 |
| 1 infection | 209 | 62.1 (58, 67) | 1.12 (0.55, 2) | 467 (336, 601) | 0.03 (-0.1, 0.24) | ||
| Number of vaccine doses (without an infection) | 1 | 659 | 64.2 (58, 70) | 1.07 (0.6, 2) | 420 (280, 578) | 0.03 (-0.12, 0.28) | <.001 for 1 & 2 vaccine doses vs. 3 vaccine doses |
| 2 | 4344 | 64.6 (59, 70) | 1.09 (0.6, 2) | 441 (298, 586) | 0.03 (-0.11, 0.23) | ||
| 3 | 1405 | 65 (59, 70) | 1.08 (0.6, 2) | 441 (360, 574) | 0.09 (-0.05, 0.34) | ||
| Number of events (infection and/or vaccination) | 1 | 868 | 63.8 (58, 69) | 1.08 (0.6, 2) | 433 (301, 582) | 0.03 (-0.12, 0.27) | <.001 for 1 & 2 events vs. 3 events |
| 2 | 4413 | 64.6 (59, 69) | 1.09 (0.6, 2) | 442 (299, 586) | 0.03 (-0.11, 0.23) | ||
| 3 | 1448 | 65.1 (59, 70) | 1.08 (0.6, 2) | 441 (360, 576) | 0.09 (-0.06, 0.33) | ||
| PSA increase according to the interval between an event and second PSA test | Event to PSA test ≤30 d | 1743 | 65 (59, 70) | 1.11 (0.6, 2.1) | 429 (301, 581) | 0.04 (-0.1, 0.28) | .7 |
| Event to PSA test >30 d | 4990 | 64.4 (58, 69) | 1.08 (0.6, 2) | 445 (328, 583) | 0.04 (-0.1, 0.25) | ||
| Event to PSA test ≤14 d | 907 | 64.9 (59, 70) | 1.06 (0.6, 2) | 426 (308, 580) | 0.05 (-0.1, 0.27) | .7 | |
| Event to PSA test >14 d | 5826 | 64.5 (59, 69) | 1.09 (0.6, 2) | 442 (325, 583) | 0.04 (-0.1, 0.26) | ||
| PSA increase according to the interval between infection and second PSA test | Infection to PSA test ≤30 d | 42 | 63.2 (58, 68) | 1.02 (0.5, 2) | 447 (310, 616) | 0.05 (-0.05, 0.36) | .3 |
| Infection to PSA test >30 d | 283 | 62.1 (58, 67) | 1.11 (0.6, 2) | 476 (337, 608) | 0.03 (-0.09, 0.26) |
Abbreviations: IQR = interquartile range; PSA = prostate-specific antigen.
⁎
Pearson's chi-squared.