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. Author manuscript; available in PMC: 2024 May 1.
Published in final edited form as: JAMA Intern Med. 2023 May 1;183(5):401–402. doi: 10.1001/jamainternmed.2023.0116

Table:

Universal Precautions to Prevent Overdose

Offer medications to individuals with opioid use disorder interested in reducing their use or managing overdose risk
Provide naloxone to people who use drugs and ensure training on its proper use
Offer take-home fentanyl test strips to people who use opioids or other drugs that may be fentanyl-contaminated (e.g., cocaine, methamphetamine, or pills purchased in the illicit market)
Counsel people who use drugs on how to reduce their risk of fatal overdose:
 • Never use alone
 • Start with only a small amount of a drug to assess its potency
 • Avoid mixing opioids and other sedatives (e.g., benzodiazepines, alcohol)