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. Author manuscript; available in PMC: 2024 May 2.
Published in final edited form as: Cell Metab. 2023 Apr 20;35(5):855–874.e5. doi: 10.1016/j.cmet.2023.03.022

Figure 3. Lowering S1P production or signaling improves neuronal function.

Figure 3.

(A) Schematic illustrating how VLCFA in glia may lead to neurodegeneration. (B) Neuronal expression of either UAS-sply or UAS-SGPL1 suppresses the progressive climbing defects observed in flies (Repo-lexA/lexop-ELOVL1) at Day 20 (n>12). (C) Supplementation of either Bezafibrate or Fingolimod can significantly suppress the lethality observed in dACOX1T2A mutant flies. Quantification of the percentage of expected animals per cross (n>4). (D) Bezafibrate and Fingolimod rescued the ERG amplitude defects of homozygous dACOX1T2A flies at Day 15 (n>10 per genotype). Statistical analyses are one-way ANOVA followed by a Tukey post hoc test. Results are mean ± s.e.m. (****p < 0.0001, ***p < 0.001, **p < 0.01; n.s., not significant).