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. Author manuscript; available in PMC: 2024 May 2.
Published in final edited form as: Cell Metab. 2023 Apr 20;35(5):855–874.e5. doi: 10.1016/j.cmet.2023.03.022

Figure 5. Glial VLCFA/S1P accumulation induces a robust immune response via the IMD pathway.

Figure 5.

(A) Melanization is observed in numerous tissues of dACOX1 mutant flies (dACOX1T2A). These are not observed in control flies (dACOX1T2A;GR). (B) Repo>ELOVL1 and Repo>SK1 induce a robust elevation of the AntiMicrobacterial Peptides (AMPs) dependent on the IMD pathway but not the Toll pathway in adult heads (80> heads of flies were used per genotype. n=3). (C) Expression of Relish RNAi suppresses the short life span (n>50 per genotype) observed in Repo>ELOVL1 flies. (D) Sphingolipid profiling in heads of yw (control) and CDase mutants (yw;CDasenull) (n=500 for each genotype). (E) Fold changes of the levels of AMPs in control (yw), CDase null flies (yw;CDasenull) (n>30 heads of flies were used per genotype. n=3).