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. 2023 May 4;14:2573. doi: 10.1038/s41467-023-38165-6

Fig. 6. Treatment with acNPs reverses liver steatosis in high-fat diet-fed mice.

Fig. 6

A Multiple injections of LD or HD acNPs to mice result in significant liver weight reduction, with more significant reductions with  HD acNPs (n = 12 animals per group). B Multiple injections of LD or HD acNPs to LFD mice do not result in significant liver reduction (n = 12 animals per group). C Liver triglycerides level measured in mice across all treatment conditions (n = 12 animals per group). LD and HD acNPs result in liver triglyceride reduction, with HD acNPs having a greater response. Two-tailed unpaired t-test (A, B, C); data are expressed as means ± SD. n.s. not statistically significant. D–F Representative H & E stains of mice liver tissue slices from different treatments. Bar, 50 μm. Black arrows indicate lipid droplets or microvesicular steatosis (n = 3 animals were used for each treatment condition). G The degree of steatosis is determined with a histopathological grid (Supplementary Table. 3) and scored blindly by a pathologist. Source data are available as a Source Data file.