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. 2023 May 4;14:2586. doi: 10.1038/s41467-023-38186-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b Active subnetwork enrichment analysis of KEGG pathways in genes differentially expressed in CNVneg glioma-associated astrocytes compared to CNVpos glioma cells in primary and recurrent IDH-WT glioma. Fold-enrichment is represented on the x-axis and the pathways in the y-axis. The pathways are clustered to denote shared genes driving enrichment. Significance was calculated using a Fisher exact test. The size of the circle per pathway denotes the number of enriched genes, and the negative log10 of the Bonferroni adjusted p-value is represented by color. Pathways enriched in genes significantly higher in astrocytes compared to glioma cells are shown in a and include neurodegenerative diseases and oxidative phosphorylation, metabolism including fatty acid metabolism. Pathways enriched in genes significantly higher in glioma cells compared to astrocytes are shown in b and include DNA replication, splicing, and ErbB signaling.