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. 2023 May 4;13:7276. doi: 10.1038/s41598-023-34182-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptomic analysis revealed disrupted intestinal barrier in Ulcerative colitis (UC) and irritable bowel syndrome (IBS). (a) Volcano plots presenting the intestinal differentially expressed genes (DEGs) between UC and CON, IBS and CON. (b) Heatmaps showing the top 30 differentially expressed genes. There were some inflammatory-related genes in UC vs. CON, such as Il6, Il1b and Il33, and some cell motility-related genes in IBS vs. CON, such as Gm8488 and Myh9. (c) Enrichment plots from inflammatory-related gene set enrichment analysis (GSEA). (d) Enrichment plots from gene set enrichment analysis about intestinal mucus barrier, epithelial barrier, gut vascular barrier.