Table 1.
Fold change of metabolite levels in DMSO vehicle-treated conditioned media (CM_Vehicle) of HCT116 compared to control media without cells (Control).
| Metabolite | log2 (fold change, downregulated) | Metabolite | log2 (fold change, upregulated) |
|---|---|---|---|
| Hypoxanthine | −6.49 | S-Adenosyl-L-Homocysteine | 7.03 |
| Niacin/ Nicotinate | −5.64 | Glycerol 3-phosphate | 5.94 |
| Linoleic acid | −4.79 | Alpha-Ketoglutarate | 3.95 |
| Cytidine | −4.69 | Orotic acid | 3.80 |
| Glutamine | −4.45 | Pyruvate | 3.25 |
| Adenine | −2.95 | Lactate | 2.91 |
| Serine | −2.28 | N-acetylaspartate | 2.85 |
| Taurine | −1.90 | Serotonin | 1.59 |
| Oleic acid | −1.74 | Pyridoxal | 1.26 |
| Hexanoylcarnitine | −1.51 | Acetyllysine | 0.94 |
| Palmitoleic acid | −1.44 | Decanoic acid | 0.70 |
| Tryptophan | −1.39 | Nicotinamide | 0.65 |
| Creatine | −1.39 | Malate | 0.61 |
| Cystine | −1.14 | Asparagine | 0.57 |
| Leucine | −1.01 | Fumarate | 0.45 |
| Lysine | −0.99 | Urate | 0.40 |
| Methionine | −0.94 | Glutamate | 0.40 |
| Acetylglutamine | −0.92 | Glycine | 0.34 |
| Ornithine | −0.88 | L-Kynurenine | 0.24 |
| Valine | −0.84 | Fructose | 0.20 |
| Threonine | −0.80 | Creatinine | 0.19 |
| Glucose | −0.69 | ||
| Tyrosine | −0.66 | ||
| L-Alanine | −0.50 | ||
| L-Sarcosine | −0.50 | ||
| Histidine | −0.50 | ||
| Phenylalanine | −0.49 | ||
| Cysteine sulfinic acid | −0.47 | ||
| IsoLeucine | −0.46 | ||
| Carnitine | −0.45 | ||
| Aspartate | −0.36 |