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. 2023 May 5;14(5):306. doi: 10.1038/s41419-023-05806-z

Table 2.

Fold change of metabolite levels in DMSO vehicle-treated conditioned media (CM_Vehicle) of LoVo compared to control media without cells (Control).

Metabolite log2 (fold change, downregulated) Metabolite log2 (fold change, upregulated)
Docosahexaenoic acid −6.75 Acetylcysteine 9.11
Niacin/ Nicotinate −6.73 Orotic acid 6.29
Hypoxanthine −6.48 Alpha-Ketoglutarate 4.10
Cytidine −5.38 N-Acetylaspartate 3.54
Glutamine −4.78 Glycerol 3-phosphate 3.45
Linoleic acid −2.89 Lactate 2.97
Serine −2.53 Pyruvate 2.86
Taurine −2.09 Cysteine 2.23
Tryptophan −2.05 Butyric acid 2.06
Palmitoleic acid −1.91 Serotonin 1.99
Creatine −1.71 Pyridoxal 1.93
Oleic acid −1.43 Acetyl-lysine 1.67
L-Alanine −1.32 Cis-aconitate 1.35
L-Sarcosine −1.32 Nicotinamide 1.02
Methionine −1.29 Butyryl-carnitine 0.92
Threonine −0.98 Malate 0.72
Lysine −0.85 Fumarate 0.53
Tyrosine −0.85 L-Kynurenine 0.40
Glucose −0.83 Citrulline 0.33
Cysteinesulfinic acid −0.76 Riboflavin 0.29
Carnitine −0.75 Acetylcarnitine 0.28
IsoLeucine −0.73 Creatinine 0.24
Aspartate −0.72 Glycine 0.22
Leucine −0.68 Pantothenate 0.22
Phenylalanine −0.67 Glutamate 0.22
Histidine −0.65