Table 2.

Fold change of metabolite levels in DMSO vehicle-treated conditioned media (CM_Vehicle) of LoVo compared to control media without cells (Control).

Metabolite	log2 (fold change, downregulated)	Metabolite	log2 (fold change, upregulated)
Docosahexaenoic acid	−6.75	Acetylcysteine	9.11
Niacin/ Nicotinate	−6.73	Orotic acid	6.29
Hypoxanthine	−6.48	Alpha-Ketoglutarate	4.10
Cytidine	−5.38	N-Acetylaspartate	3.54
Glutamine	−4.78	Glycerol 3-phosphate	3.45
Linoleic acid	−2.89	Lactate	2.97
Serine	−2.53	Pyruvate	2.86
Taurine	−2.09	Cysteine	2.23
Tryptophan	−2.05	Butyric acid	2.06
Palmitoleic acid	−1.91	Serotonin	1.99
Creatine	−1.71	Pyridoxal	1.93
Oleic acid	−1.43	Acetyl-lysine	1.67
L-Alanine	−1.32	Cis-aconitate	1.35
L-Sarcosine	−1.32	Nicotinamide	1.02
Methionine	−1.29	Butyryl-carnitine	0.92
Threonine	−0.98	Malate	0.72
Lysine	−0.85	Fumarate	0.53
Tyrosine	−0.85	L-Kynurenine	0.40
Glucose	−0.83	Citrulline	0.33
Cysteinesulfinic acid	−0.76	Riboflavin	0.29
Carnitine	−0.75	Acetylcarnitine	0.28
IsoLeucine	−0.73	Creatinine	0.24
Aspartate	−0.72	Glycine	0.22
Leucine	−0.68	Pantothenate	0.22
Phenylalanine	−0.67	Glutamate	0.22
Histidine	−0.65