Table 3.
Overlap of fold change of metabolite levels in 5-FU treated conditioned media (CM_5-FU) of HCT116 and LoVo compared to DMSO vehicle-treated conditioned media (CM_Vehicle).
| Metabolite | log2 (fold change, downregulated) | Metabolite | log2 (fold change, upregulated) | ||
|---|---|---|---|---|---|
| HCT116 | LoVo | HCT116 | LoVo | ||
| Lactate | −1.01 | −0.93 | Glutamine | 4.02 | 4.03 |
| Acetyllysine | −0.53 | −0.79 | Niacin/ Nicotinate | 2.96 | 1.85 |
| Fructose | −0.20 | −0.24 | Linoleic acid | 2.81 | 1.78 |
| Hypoxanthine | 2.24 | 1.65 | |||
| Palmitoleic acid | 1.74 | 1.65 | |||
| Serine | 1.66 | 1.51 | |||
| Oleic acid | 1.55 | 1.49 | |||
| Tryptophan | 1.18 | 1.26 | |||
| Lysine | 0.88 | 1.26 | |||
| Creatine | 0.84 | 1.09 | |||
| Pyruvate | 0.79 | 1.05 | |||
| Methionine | 0.71 | 0.93 | |||
| Threonine | 0.56 | 0.78 | |||
| Tyrosine | 0.50 | 0.77 | |||
| L-Alanine | 0.44 | 0.76 | |||
| L-Sarcosine | 0.44 | 0.70 | |||
| Cytidine | 0.42 | 0.55 | |||
| Phenylalanine | 0.37 | 0.50 | |||
| IsoLeucine | 0.33 | 0.40 | |||