Table 1.
Estimates of depression on gastrointestinal diseases mediated by potential mediators.
| Gastrointestinal diseases | Cases/Controls | Adjustment for BMI | Adjustment for smoking initiation | Adjustment for type 2 diabetes mellitus | Adjustment for body mass index, smoking initiation, and type 2 diabetes mellitus | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | P value | Mediation effect (%) | OR (95% CI) | P value | Mediation effect (%) | OR (95% CI) | P value | Mediation effect (%) | OR (95% CI) | P value | Mediation effect (%) | ||
| Gastroesophageal reflux | 34,135/634,629 | 1.31 (1.20, 1.44) | 7.31E-09 | 3.79% | 1.32 (1.15, 1.52) | 8.67E-05 | 7.24% | 1.39 (1.24, 1.56) | 3.32E-08 | 2.39% | 1.30 (1.19, 1.42) | 1.68E-08 | 10.76% |
| Gastric ulcer | 8651/666,879 | 1.24 (1.04, 1.47) | 0.017 | 6.57% | 1.34 (1.06, 1.70) | 0.014 | 16.34% | 1.33 (1.09, 1.64) | 7.83E-04 | 4.60% | 1.28 (1.08, 1.52) | 0.004 | 18.34% |
| Duodenal ulcer | 5713/666,879 | 1.20 (0.96, 1.48) | 0.102 | 11.51% | 1.12 (0.82, 1.54) | 0.481 | 19.67% | 1.26 (0.94, 1.68) | 0.118 | 5.34% | 1.19 (0.97, 1.47) | 0.101 | 23.69% |
| Chronic gastritis | 7975/643,478 | 1.16 (1.02, 1.33) | 0.028 | 7.08% | 1.20 (0.99, 1.45) | 0.059 | 13.45% | 1.30 (1.10, 1.55) | 0.003 | 5.30% | 1.15 (1.00, 1.31) | 0.043 | 29.14% |
| Irritable bowel disease | 12,601/587,969 | 1.29 (1.22, 1.36) | 3.89E-20 | 8.82% | 1.28 (1.18, 1.38) | 6.94E-10 | 14.92% | 1.30 (1.21, 1.40) | 1.94E-12 | 4.55% | 1.27 (1.20, 1.34) | 7.10E-18 | 20.64% |
| Diverticular disease | 50,065/587,969 | 1.27 (1.15, 1.40) | 1.05E-06 | 4.26% | 1.23 (1.07, 1.41) | 0.003 | 9.99% | 1.22 (1.08, 1.38) | 0.002 | 2.75% | 1.26 (1.15, 1.39) | 1.21E-06 | 10.30% |
| Ulcerative colitis | 9,802/630,791 | 1.15 (1.04, 1.27) | 0.005 | −4.93% | 1.23 (1.05, 1.44) | 0.011 | −11.21% | 1.12 (0.97, 1.28) | 0.115 | 7.12% | 1.19 (1.08, 1.32) | 6.41E-04 | 3.42% |
| Non-alcoholic fatty liver disease | 3,242/707,631 | 1.05 (0.78, 1.42) | 0.735 | 49.28% | 1.27 (0.87, 1.85) | 0.213 | 7.89% | 1.35 (0.84, 2.18) | 0.220 | 17.70% | 1.09 (0.80, 1.49) | 0.597 | 53.54% |
| Alcoholic liver disease | 2,955/680,369 | 1.32 (1.03, 1.69) | 0.027 | 4.48% | 1.26 (0.91, 1.74) | 0.157 | 34.13% | 1.28 (0.89, 1.83) | 0.183 | 3.27% | 1.21 (0.94, 1.56) | 0.131 | 36.43% |
| Cholelithiasis | 5,893/664,749 | 1.13 (1.03, 1.24) | 0.007 | 23.46% | 1.18 (1.05, 1.33) | 0.005 | 3.18% | 1.17 (1.01, 1.37) | 0.041 | 9.30% | 1.14 (1.03, 1.25) | 0.008 | 18.06% |
| Acute pancreatitis | 6,634/679,713 | 1.18 (0.99, 1.40) | 0.068 | 11.01% | 1.07 (0.86, 1.34) | 0.532 | 45.02% | 1.12 (0.91, 1.37) | 0.295 | 7.36% | 1.13 (0.95, 1.34) | 0.152 | 38.08% |
| Chronic pancreatitis | 3,173/679,713 | 1.41 (1.16, 1.72) | 7.18E-04 | 0.91% | 1.10 (0.86, 1.40) | 0.435 | 26.79% | 0.97 (0.88, 1.08) | 0.585 | −2.70% | 1.02 (0.95, 1.11) | 0.557 | 44.07% |
OR odds radio, CI confidence interval.