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. 2022 Dec 9;55(3):438–448. doi: 10.3724/abbs.2022178

Figure 4 .

Figure 4

circ-BPTF sponges miR-486-5p

(A) Bioinformatics software (miRanda and RNAhybrid) predicted miRNAs that could bind to circ-BPTF. (B) Human PASMCs were exposed to hypoxia for 24 h, and qPCR was used to detect miR-202-3p, miR-758-3p, miR-486-5p and miR-218-5p expression levels. (C) The predicted binding sites of circ-BPTF and miR-486-5p by TargetScan. (D) Dual luciferase reporter assays demonstrated the interactions between circ-BPTF and miR-486-5p. (E) Human PASMCs were transfected with circ-BPTF-specific siRNA (si-BPTF) or negative control siRNA (si-NC) before exposure to hypoxia for 24 h. qPCR was used to detect miR-486-5p level. * P<0.05, ** P<0.01.