Table 2.
Frequency and Odds of 30-Day Mortality for by Qualifying Comorbidity Sets for Heart Failure Patients
| Qualifying Comorbidity Sets* | Frequency (%) 314,510 (100.00) |
Ref. non-MM† (N=36,634) | Ref. typical† (N=73,702) |
||
|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | ||
| A. Top 10 QCS listed by highest to lowest frequency | |||||
| Protein-Calorie Malnutrition | 32,385 (10.30) | 4.83 | (4.53, 5.15) | 2.39 | (2.29, 2.49) |
| Thrombocytopenia and Other Hematological Disorders | Acute Heart or Respiratory Failure | Heart Failure | 31,018 (9.86) | 3.84 | (3.59, 4.11) | 1.91 | (1.83, 2.00) |
| Acute Heart or Respiratory Failure | Heart Failure | Acute Myocardial Infarction | 30,717 (9.77) | 3.67 | (3.43, 3.93) | 1.81 | (1.73, 1.90) |
| Sepsis or Septic Shock | Acute Heart or Respiratory Failure | 29,982 (9.53) | 3.61 | (3.37, 3.86) | 1.79 | (1.71, 1.87) |
| Acute Heart or Respiratory Failure | Pneumonias | 29,660 (9.43) | 3.61 | (3.37, 3.86) | 1.79 | (1.71, 1.87) |
| Thrombocytopenia and Other Hematological Disorders | Acute Heart or Respiratory Failure | Coronary Artery Disease | 27,477 (8.74) | 3.80 | (3.55, 4.07) | 1.89 | (1.81, 1.98) |
| Thrombocytopenia and Other Hematological Disorders | Acute Heart or Respiratory Failure | Cardiac Arrhythmias | 27,340 (8.69) | 3.96 | (3.70, 4.23) | 1.98 | (1.89, 2.07) |
| Heart Failure | Cardiac Arrhythmias | Pneumonias | 26,873 (8.54) | 3.46 | (3.23, 3.70) | 1.72 | (1.64, 1.81) |
| Acute Heart or Respiratory Failure | Cardiac Arrhythmias | CKD Stage 4-5 or Dialysis | 26,556 (8.44) | 3.81 | (3.53, 4.12) | 1.84 | (1.75, 1.93) |
| Acute Heart or Respiratory Failure | Chronic Pulmonary Diseases | CKD Stage 4-5 or Dialysis | 26,183 (8.33) | 3.48 | (3.21, 3.76) | 1.67 | (1.59, 1.76) |
| B. Top 5 QCS listed by highest to lowest odds of mortality‡ | |||||
| Thrombocytopenia and Other Hematological Disorders | Chronic Non-Pressure Skin Ulcers | Home Oxygen Use | 2394 (0.76) | 4.93 | (4.34, 5.59) | 2.44 | (2.17, 2.73) |
| Protein-Calorie Malnutrition | 32,385 (10.30) | 4.83 | (4.53, 5.15) | 2.39 | (2.29, 2.49) |
| Thrombocytopenia and Other Hematological Disorders | Home Hospital Bed or Wheelchair use | Home Oxygen Use | 1713 (0.55) | 4.82 | (4.16, 5.58) | 2.38 | (2.08, 2.73) |
| Thrombocytopenia and Other Hematological Disorders | Acute Heart or Respiratory Failure | Chronic Non-Pressure Skin Ulcers | 6210 (1.98) | 4.79 | (4.36, 5.26) | 2.37 | (2.20, 2.56) |
| Thrombocytopenia and Other Hematological Disorders | CKD Stage 4-5 or Dialysis | Home Oxygen Use | 4248 (1.35) | 4.75 | (4.26,5.30) | 2.30 | (2.10,2.51) |
| C. Patients for MM definition development and MC/ADRD/90 patients | |||||
| Patients for MM definition development | 314,510 (100.00) | ||||
| MM | 167,739 (53.33) | 2.97 | (2.80, 3.15) | 1.47 | (1.42, 1.52) |
| Non-MM | 146,771 (46.67) | -- | -- | 0.51 | (0.49, 0.53) |
| MC/ADRD/90 patients§ | 220,046 (100.00) | ||||
| MM | 134,116 (60.95) | 4.92 | (4.63, 5.22) | 2.42 | (2.34, 2.51) |
| Non-MM | 85,930 (39.05) | 2.22 | (2.08, 2.37) | 1.13 | (1.08, 1.18) |
* The full list of 118 QCSs with their frequency and ORs (95% CI) are provided in Appendix G (Table G.2)
† Typical reference group consisting of a random 20% sample of 2018-2019 admissions. Patients with Metastatic Cancers, ADRD, age ≥90 years, or on dialysis were not included in the typical reference group.; Non-multimorbid reference group drawn from the same random 20% sample comprised of patients who do not have any QCSs as well as patients without Metastatic Cancers, ADRD, or age ≥90 years. Dashes (--) indicate a population odds ratio of 1, reflecting the fact that the comparison groups are a random split of one population
‡Ranked by lower 95% CI of odds for 30-day mortality relative to the medical condition-specific typical reference population
§Frequency and odds of 30-day mortality for multimorbid and non-multimorbid patients with Metastatic Cancers, ADRD, or age ≥90 years are further detailed in Appendix G (Table G.4)