Table 3.
Frequency and Odds of 30-day Mortality with Qualifying Comorbidity Sets for Pneumonia Patients
| Qualifying Comorbidity Sets* |
Frequency (%) 385,219 (100.00) |
Ref. non-MM† (N=41,667) |
Ref. typical† (N=92,169) |
||
|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | ||
| A. Top 10 QCS listed by highest to lowest frequency | |||||
| Acute Heart or Respiratory Failure | Acute Renal Failure | 72,024 (18.70) | 7.02 | (6.66, 7.40) | 2.24 | (2.18, 2.30) |
| Protein-Calorie Malnutrition | 65,651 (17.04) | 7.40 | (7.02, 7.80) | 2.33 | (2.26, 2.39) |
| Thrombocytopenia and Other Hematological Disorders | Acute Heart or Respiratory Failure | 45,920 (11.92) | 7.44 | (7.04, 7.85) | 2.38 | (2.31, 2.45) |
| Acute Myocardial Infarction | 44,534 (11.56) | 6.32 | (5.99, 6.68) | 2.03 | (1.97, 2.09) |
| Acute Heart or Respiratory Failure | CKD Stage 4–5 or Dialysis | 32,157 (8.35) | 7.02 | (6.64, 7.43) | 2.25 | (2.18, 2.33) |
| Thrombocytopenia and Other Hematological Disorders | Acute Renal Failure | 27,175 (7.05) | 7.60 | (7.18, 8.05) | 2.45 | (2.36, 2.53) |
| Sepsis or Septic Shock | Acute Heart or Respiratory Failure | Cardiac Arrhythmias | 25,336 (6.58) | 7.09 | (6.69, 7.52) | 2.26 | (2.18, 2.34) |
| Pressure Ulcer of Skin | 24,347 (6.32) | 8.09 | (7.63, 8.57) | 2.57 | (2.48, 2.66) |
| Acute Heart or Respiratory Failure | Chronic Non-Pressure Skin Ulcers | 23,400 (6.07) | 7.29 | (6.87, 7.73) | 2.33 | (2.25, 2.42) |
| Liver Disease | 18,672 (4.85) | 7.68 | (7.21, 8.19) | 2.45 | (2.35, 2.55) |
| B. Top 5 QCS listed by highest to lowest odds of mortality‡ | |||||
| Cardiac Arrhythmias | CKD Stage 4-5 or Dialysis | Other Trauma | 3072 (0.80) | 8.46 | (7.69, 9.31) | 2.76 | (2.55, 3.00) |
| Cardiac Arrhythmias | Chronic Non-Pressure Skin Ulcers | Complications of Implants or Grafts | 4071 (1.06) | 8.54 | (7.82, 9.32) | 2.75 | (2.56, 2.96) |
| Sepsis or Septic Shock | Cardiac Arrhythmias | CKD Stage 4-5 or Dialysis | 8654 (2.25) | 8.05 | (7.50, 8.64) | 2.60 | (2.46, 2.74) |
| Sepsis or Septic Shock | Cardiac Arrhythmias | Chronic Non-Pressure Skin Ulcers | 7327 (1.90) | 8.07 | (7.50, 8.69) | 2.60 | (2.46, 2.76) |
| Pressure Ulcer of Skin | 24,347 (6.32) | 8.09 | (7.63, 8.57) | 2.57 | (2.48, 2.66) |
| C. Patients for MM definition development and MC/ADRD/90 patients | |||||
| Patients for MM definition development | 385,219 (100.00) | ||||
| MM | 220,093 (57.14) | 5.17 | (4.91, 5.44) | 1.65 | (1.62, 1.69) |
| Non-MM | 165,126 (42.87) | -- | -- | 0.32 | (0.31, 0.33) |
| MC/ADRD/90 patients§ | 434,165 (100.00) | ||||
| MM | 295,663 (68.10) | 9.99 | (9.50, 10.51) | 3.11 | (3.05, 3.18) |
| Non-MM | 138,502 (31.90) | 2.85 | (2.70, 3.01) | 0.93 | (0.90, 0.96) |
* The full list of 51 QCSs with their frequency and ORs (95% CI) are provided in Appendix G (Table G.3)
† Typical reference group consisting of a random 20% sample of 2018-2019 admissions. Patients with Metastatic Cancers, ADRD, age ≥90 years, or on dialysis were not included in the typical reference group.; Non-multimorbid reference group drawn from the same random 20% sample comprised of patients who do not have any QCSs as well as patients without Metastatic Cancers, ADRD, or age ≥90 years. Dashes (--) indicate a population odds ratio of 1, reflecting the fact that the comparison groups are a random split of one population
‡Ranked by lower 95% CI of odds for 30-day mortality relative to the medical condition-specific typical reference population
§Frequency and odds of 30-day mortality for multimorbid and non-multimorbid patients with Metastatic Cancers, ADRD, or age ≥90 years are further detailed in Appendix G (Table G.4)