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. 2023 Apr 21;14:1144945. doi: 10.3389/fgene.2023.1144945

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Copyright © 2023 Tang, An, Gu, Yi, Hu, Wu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GO and KEGG analyses of the DEGs. (A) The top 15 upregulated GO BP terms of the DEGs were identified by GO analysis. (B) The top 15 downregulated GO BP terms of the DEGs were identified by GO analysis. (C) The top 20 enriched pathways of the DEGs, including the top 10 activated and 10 suppressed pathways, were identified by KEGG enrichment analysis. (D–G) GSEA plots of specific activated pathway terms, including PI3K-Akt, TGF-beta, neuroactive ligand‒receptor interaction, and ECM-receptor interaction signaling pathway. (H) Further signaling pathway analysis by subtype revealed that some classical pathways, the VEGF, MAPK, PI3K, TGFb, WNT, estrogen, and p53 pathways, were activated.