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. 2023 Apr 21;14:1144945. doi: 10.3389/fgene.2023.1144945

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Copyright © 2023 Tang, An, Gu, Yi, Hu, Wu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The levels of immune cells, endothelial cells, and fibroblasts in ACC tissues and downregulated DEGs in the GO BP enrichment. (A) The levels of CD3⁺ T-cells, CD8⁺ T-cells, cytotoxic lymphocytes, natural killer cells, B lymphocytes, monocytic lineage cells, myeloid dendritic cells, neutrophils, endothelial cells and fibroblasts in ACC. (B–C) Downregulated genes involved in leukocyte migration and the adaptive immune response. (D–I) Downregulated genes involved in leukocyte migration, including CCL5, CCL19, CCL20, CCL21, CXCL6, and CXCL12. (J–Q) Downregulated B-cell-related genes, including CD19, CR2, CD79A, CD40, CD74, JCHAIN, IGHM, and IGHV3-72. (R–Y) Downregulated T cell-related genes, including CD3E, CD3G, CD4, CD8A, CD8B, GZMA, and RPF1.