Table 1.
Components of DTIC-SLNs with resultant encapsulation efficiency of different Dacarbazine solid lipid nanoparticles (means ± S.D, n=3).
| Formula number |
Dacarbazine (mg) | Glycerol monooleate (mg) | Phosphatidylcholine (mg) | Kolliphor® P188 (%w/v) | EE (%) |
|---|---|---|---|---|---|
| DTIC-SLNs-1 | 15 | 75 | 5.5 | 1.0 | 51.56±1.78 |
| DTIC-SLNs-2 | 15 | 75 | 5.5 | 1.2 | 58.35±3.56 |
| DTIC-SLNs-3 | 15 | 75 | 5.5 | 1.4 | 64.67±4.67 |
| DTIC-SLNs-4 | 15 | 75 | 7.5 | 1.0 | 56.78±3.78 |
| DTIC-SLNs-5 | 15 | 75 | 7.5 | 1.2 | 66.78±4.78 |
| DTIC-SLNs-6 | 15 | 75 | 7.5 | 1.4 | 67.56±2.67 |
| DTIC-SLNs-7 | 15 | 75 | 10 | 1.0 | 70.45±4.78 |
| DTIC-SLNs-8 | 15 | 75 | 10 | 1.2 | 81.67±2.78 |
| DTIC-SLNs-9 | 15 | 75 | 10 | 1.4 | 87.45±4.78 |
| DTIC-SLNs-10 | 15 | 75 | 10 | – | 37.78±2.78 |
| DTIC-SLNs-11 | 15 | 75 | – | 1.4 | 43.78±2.67 |