Table 4.
The permeation parameters of both DTIC-SLNs-8 and free DTIC in various gel bases [Gellan gum (0.01%w/v), Chitosan (0.5% w/v), Polysarcosine (2.5% w/v)] to illustrate the increase in drug permeation when loaded into SLNs and the impact of different gel bases on both the SLNs and the free drug permeation (means± SD, n=3).
| Component of the gel formula | Q24(µg/cm3) | Lag time(min) | Kp (cm/hr) |
|---|---|---|---|
| DTIC-SLNs-8 suspended in Gellan gum (0.01%w/v) | 257.12± 8.11 | 50±1.70 | 0.6261 ± 0.0121 |
| Only DTIC suspended in Gellan gum (0.01%w/v) | 127.34±3.10 | 100±1.21 | 0.0512 ± 0.0041 |
| DTIC-SLNs-8 suspended in Chitosan (0.5% w/v) | 230.26±8.09 | 60±3.10 | 0.382 ± 0.0218 |
| Only DTIC suspended in Chitosan (0.5% w/v) | 134.78±4.71 | 90±2.01 | 0.0828 ± 0.0023 |
| DTIC-SLNs-8 suspended Polysarcosine (2.5% w/v) | 139.81±6.27 | 74±7.04 | 0.2827 ±0.0036 |
| Only DTIC suspended Polysarcosine (2.5% w/v) | 163.25±9.14 | 78±2.78 | 0.1911 ±0.011 |