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. 2023 Apr 21;14:1182963. doi: 10.3389/fimmu.2023.1182963

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Copyright © 2023 Kubinski, Beicht, Zdora, Biermann, Puff, Gerlach, Tscherne, Baumgärtner, Osterhaus, Sutter, Prajeeth and Rimmelzwaan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Body weight change and survival curves of vaccinated and challenge infected mice. (A–D) Percentage of body weight change compared with initial body weight on the day of challenge during the entire course of TBEV infection for PBS- (A), MVA- (B), FSME-IMMUN^®- (C), and MVA-prME-vaccinated (D) mice. (E) Kaplan–Meier curves showing the percentage of survival of mice vaccinated with PBS (gray), MVA (black), FSME-IMMUN^® (blue, dotted), or MVA-prME (red) (n = 6, ***p≤0.001). p = 0.0007: FSME-IMMUN^®/MVA-prME versus PBS, p = 0.0004: FSME-IMMUN^®/MVA-prME versus MVA.