Table 1.
Features of the included study population.
| Exposure | Methods | Number of SNPs | OR (95% CI) | Beta (SE) | P-value | Fdr | Pleiotropy | Heterogeneity | |
|---|---|---|---|---|---|---|---|---|---|
| P- value | I2 (%) | P- value | |||||||
| 22:6, docosahexaenoic acid | IVW | 6 | 0.996 (0.982–1.010) | −0.004(0.007) | 0.577 | 0.232 | 0.862 | 38.324 | 0.150 |
| 3-hydroxybutyrate | IVW | 9 | 1.008 (0.989–1.028) | 0.008(0.010) | 0.400 | 0.197 | 0.816 | 45.775 | 0.064 |
| Acetate | IVW | 13 | 1.013 (0.995–1.031) | 0.013(0.009) | 0.159 | 0.114 | 0.739 | 52.699 | 0.013 |
| Acetoacetate | IVW | 12 | 1.021 (1.009–1.034) | 0.021(0.006) | 0.001 | 0.011 | 0.901 | 0.000 | 0.871 |
| Alanine | IVW | 6 | 1.013 (0.998–1.028) | 0.013(0.007) | 0.079 | 0.086 | 0.930 | 19.326 | 0.287 |
| Apolipoprotein A-I | IVW | 10 | 0.990 (0.981–0.999) | −0.010(0.005) | 0.036 | 0.069 | 0.666 | 34.134 | 0.135 |
| Apolipoprotein B | IVW | 16 | 0.999 (0.993–1.006) | −0.001(0.003) | 0.834 | 0.283 | 0.071 | 15.222 | 0.279 |
| Citrate | IVW | 5 | 0.997 (0.977–1.017) | −0.003(0.010) | 0.767 | 0.266 | 0.896 | 55.540 | 0.061 |
| Creatinine | IVW | 6 | 1.000 (0.984–1.016) | 0.00007(0.008) | 0.993 | 0.319 | 0.997 | 14.615 | 0.321 |
| Free cholesterol | IVW | 11 | 0.995 (0.989–1.001) | −0.005(0.003) | 0.095 | 0.090 | 0.347 | 0.000 | 0.923 |
| Glutamine | IVW | 5 | 0.985 (0.972–0.997) | −0.016(0.007) | 0.019 | 0.061 | 0.626 | 26.614 | 0.244 |
| Glycerol | IVW | 15 | 1.003 (0.994–1.011) | 0.003(0.004) | 0.537 | 0.226 | 0.367 | 0.000 | 0.972 |
| Glycoprotein acetyls | IVW | 7 | 1.007 (0.995–1.020) | 0.007(0.006) | 0.248 | 0.152 | 0.706 | 22.283 | 0.259 |
| Glycoproteins | IVW | 10 | 1.005 (1.000–1.009) | 0.005(0.002) | 0.038 | 0.070 | 0.511 | 0.000 | 0.944 |
| Histidine | IVW | 5 | 0.992 (0.971–1.015) | −0.008(0.011) | 0.501 | 0.219 | 0.545 | 56.649 | 0.056 |
| Isoleucine | IVW | 14 | 1.013 (1.002–1.024) | 0.0132(0.005) | 0.016 | 0.058 | 0.454 | 0.000 | 0.697 |
| Lactate | IVW | 12 | 1.011 (0.998–1.023) | 0.011(0.006) | 0.096 | 0.090 | 0.820 | 0.967 | 0.434 |
| Leucine | IVW | 3 | 1.005 (0.988–1.021) | 0.005(0.008) | 0.574 | 0.232 | 0.410 | 0.000 | 0.411 |
| Linoleic acid | IVW | 14 | 1.002 (0.995–1.008) | 0.002(0.003) | 0.621 | 0.239 | 0.577 | 17.890 | 0.258 |
| Omega-3 fatty acids | IVW | 6 | 0.997 (0.983–1.011) | −0.003(0.007) | 0.674 | 0.246 | 0.675 | 47.792 | 0.088 |
| Omega-6 fatty acids | IVW | 12 | 0.995 (0.988–1.002) | −0.005(0.005) | 0.167 | 0.117 | 0.541 | 0.000 | 0.702 |
| Phenylalanine | IVW | 3 | 0.994 (0.960–1.029) | −0.006(0.018) | 0.727 | 0.256 | 0.946 | 74.658 | 0.019 |
| Phosphatidylcholine and other cholines | IVW | 6 | 0.995 (0.987–1.004) | −0.005(0.004) | 0.266 | 0.158 | 0.339 | 0.000 | 0.674 |
| Total lipids in small LDL | IVW | 19 | 0.997 (0.992–1.003) | −0.003(0.003) | 0.314 | 0.174 | 0.123 | 0.000 | 0.526 |
| Pyruvate | IVW | 19 | 1.009 (0.999–1.019) | 0.009(0.005) | 0.081 | 0.086 | 0.337 | 40.173 | 0.037 |
| Serum total cholesterol | IVW | 20 | 0.996 (0.990–1.002) | −0.004(0.003) | 0.154 | 0.113 | 0.520 | 0.000 | 0.822 |
| Serum total triglycerides | IVW | 12 | 1.008 (0.998–1.019) | 0.008(0.005) | 0.107 | 0.092 | 0.505 | 46.574 | 0.038 |
| Sphingomyelins | IVW | 7 | 0.992 (0.982–1.001) | −0.008(0.005) | 0.083 | 0.087 | 0.186 | 0.000 | 0.663 |
| total fatty acid | IVW | 11 | 1.004 (0.995–1.013) | 0.004(0.004) | 0.340 | 0.182 | 0.716 | 16.218 | 0.289 |
| Total phosphoglycerides | IVW | 8 | 0.997 (0.989–1.005) | −0.003(0.004) | 0.482 | 0.215 | 0.411 | 0.000 | 0.846 |
| Valine | IVW | 5 | 1.003 (0.989–1.016) | 0.003(0.007) | 0.684 | 0.248 | 0.323 | 0.000 | 0.461 |
| Mono-unsaturated fatty acids | IVW | 7 | 1.004 (0.994–1.015) | 0.004(0.006) | 0.419 | 0.202 | 0.899 | 25.567 | 0.234 |
| Tyrosine | IVW | 4 | 1.003 (0.989–1.018) | 0.003(0.007) | 0.634 | 0.241 | 0.751 | 0.000 | 0.813 |
| Glucose | Weighted median | 3 | 1.018 (1.001–1.036) | 0.018(0.009) | 0.033 | 0.068 | 0.372 | 29.955 | 0.240 |
| Urea | Weighted median | 9 | 1.020 (1.000–1.039) | 0.020(0.010) | 0.044 | 0.071 | 0.318 | 30.467 | 0.175 |