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. 2023 Apr 21;17:1146613. doi: 10.3389/fnins.2023.1146613

Table 2.

Effect of depression on circulating metabolites.

Exposure Outcome Methods Number of SNPs OR (95% CI) Beta (SE) p-value Fdr Pleiotropy Heterogeneity
P- value I2 (%) P- value
Depression Acetoacetate IVW 13 1.178 (0.534–2.599) 0.164 (0.404) 0.685 0.702 0.581 0.000 0.734
Apolipoprotein A-I IVW 13 0.800 (0.358–1.782) −0.223(0.409) 0.585 0.668 0.759 0.000 0.852
Glucose IVW 13 1.028 (0.497–2.127) 0.028 (0.371) 0.940 0.764 0.978 0.000 0.540
Glutamine IVW 13 0.569 (0.276–1.170) −0.564(0.368) 0.125 0.339 0.596 0.000 0.933
Glycoproteins IVW 13 1.982 (0.873–4.501) 0.684 (0.419) 0.102 0.339 0.542 0.000 0.780
Isoleucine IVW 13 1.614(0.791–3.293) 0.479(0.364) 0.188 0.393 0.397 0.000 0.886
Urea IVW 13 1.349(0.545–3.338) 0.299 (0.462) 0.518 0.641 0.164 22.526 0.216