FIG. 5.

TBF levels measured in the serum at 1 to 1.5, 2 to 2.5, 4, and 14 h postdosing. Bars represent mean concentrations for two rabbits for all four time points on day 11, for the first three time points on day 18, and for the second and fourth time points on day 25. The means for three animals are shown for the first and third time points on day 25. One animal provided the concentration for last time point on day 18. On day 32 (data not shown), five animals had mean concentrations of 0.08 ± 0.18 μg/ml. No TBF was detectable in the CSF of any animal (days 7 to 32 postinfection for 31 samples, 1 to 14.5 h postdosing for 25 samples, and 44 to 161 h postdosing for six samples).