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. 2023 May 5;13:7306. doi: 10.1038/s41598-023-33443-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Viral load in NPS samples and neutralization capacity of convalescent serum of reinfected individuals. (a) Real-time RT-PCR Ct value distribution of NPS SARS-CoV-2 positive samples taken from 25 individuals at primo-infection and reinfection. Each line represents a single individual. (b) Number of iSNVs at primo-infection and reinfection samples. Two-tailed P value was calculated with the Wilcoxon matched-pairs signed-rank test. NS Non-significant. (c) Individual trajectories of neutralization titers (PRNT₉₀) against different SARS-CoV-2 lineages in convalescent plasma from 14 individuals collected 10–75 days following SARS-CoV-2 reinfection. Each line represents a single individual. (d) Comparison of neutralization titers (PRNT₉₀) against VOCs Gamma, Delta and Omicron in convalescent plasma from hospitalized individuals primo-infected with Gamma (n = 30; Gamma-PI) and individuals reinfected with Gamma (n = 14; Gamma-RI). Horizontal bars represent sample medians and interquartile range. The dashed line indicates the detection limit of the PRNT₉₀ assay. Two-tailed P values calculated with the Wilcoxon matched-pairs signed-rank test (a,b) or the Mann–Whitney test (c) are shown.