FIG. 1.

Peptidyltransferase region of domain V of the 23S rRNA (E. coli numbering). The residues that when mutated confer resistance (R) to protein synthesis inhibitors are circled. Mutations that confer resistance to evernimicin are indicated (SCH27899^R). Residues which are protected (P) from modification by bound drug are boxed (26). Residues protected by tRNA bound in the A and P sites are labeled with the symbols ⧫ and ■, respectively (15). M, macrolides; L, lincosamides; S, streptogramin B; Cam, chloramphenicol; Ery, erythromycin.