TABLE 4.

Frequency of transformation of S. pneumoniae R6 to erythromycin resistance with a 23S rDNA allele containing an A2058G substitution at the equivalent E. coli position

Time (h)	Transformation frequency at erythromycin concn (μg/ml)a:
	0.06	0.12	0.25	0.5	1.0	2.0
24	tntc	5.6 × 10−6	1.2 × 10−6	NG	NG	NG
48	tntc	tntc	2.5 × 10−5	1.1 × 10−5	8.0 × 10−6	NG
72	tntc	tntc	4.5 × 10−5	1.4 × 10−5	1.1 × 10−5	NG

^aAbbreviations: NG, no growth; tntc, too numerous to count.