Fig. 6.
aCD47/PF hydrogel induces durable antitumor immune response. (A) The experimental scheme showing the treatment schedule as well as the timing of the rechallenge. (B) In vivo bioluminescence images of the GL-261 tumors of naïve and rechallenged mice taken on days 6, 13, and 20 post tumoral rechallenge. (C) Quantification of bioluminescence imaging of naïve and rechallenged mice in the indicated treatment groups. (D) Survival curves for naive and rechallenged mice corresponding to the indicated treatment groups. Statistical significance was determined via the log-rank (Mantel–Cox) test. (E) The percentage of CD4+ Tem cells and (F) CD8+ Tem cells in splenocytes of the naïve and rechallenged mice. Statistical significance was determined using a two-sided unpaired t test. Data are given as mean ± SD (n = 3). *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.