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. 2023 Apr 13;34(5):836–846. doi: 10.1021/jasms.2c00336

Figure 3.

Figure 3

MALDI-MS images of carboxyl- and aldehyde-containing metabolites acquired from a rat brain tissue section. Images A–D illustrate the distribution of DOPAL, images E–H illustrate the distribution of HVA, and images I–L demonstrate the distribution of GABA; in all cases, AMPP is employed as the derivatization agent in the presence of four different peptide coupling reagents (TOTU, EDCl, HATU, and HBTU). MALDI–MSI experiments were performed on direct consecutive sections for each coupling reagent. Data are shown using a rainbow scale (ion intensity scale) for optimal visualization. Lateral resolution, 100 μm.