TABLE 1.
Summary statistics for COPDGene Phase 1, COPDGene Phase 2, and SPIROMICS cohorts for GOLD 0 subjects.
| COPDGene P1 | COPDGene P2 | p-value COPDGene P2 vs. COPDGene P1 | COPDGene P3 | p-value COPDGene P3 vs. COPDGene P1 | SPIROMICS | p-value SPIROMICS vs. COPDGene P1 | |
|---|---|---|---|---|---|---|---|
| GOLD 0 totals | 2,298 | 665 | 839 | 385 | |||
| Rapid decline (>1.5% FEV1%pred) | 26.5% | 27.4% | *p = 0.62 | 12.8% | *p = 0.94 | 14.0% | *p = 0.71 |
| Male | 51.8% | 55.0% | *p = 0.47 | 52.7% | *p = 0.58 | 55.8% | *p = 0.27 |
| White | 31.0% | 25.6% | *p = 0.68 | 30.9% | *p = 0.68 | 49.3% | *p = 0.22 |
| Current smokers | 48.9% | 33.5% | *p = 0.69 | 48.5% | *p = 0.61 | 42.9% | *p = 0.38 |
| Lower lobe PRMfSAD > 10% | 10.6% | 7.4 | *p = 0.85 | 10.5% | *p = 0.81 | 6.2% | *p = 0.79 |
| Upper lobe PRMemphysema > 2% | 14.4% | 11.9 | *p = 0.78 | 15.7% | *p = 0.75 | 10.1% | *p = 0.7 |
| Age (years) | 58.0 ± 8.5 | 63.6 ± 8.3 | p < 0.001 | 57.6 ± 8.3 | p = 0.26 | 61.9 ± 9.3 | p < 0.001 |
| Height (cm) | 169.9 ± 9.4 | 168.4 ± 9.2 | p < 0.001 | 169.7 ± 9.2 | p = 0.73 | 169.1 ± 9.4 | p = 0.13 |
| Weight (kg) | 84.4 ± 18.4 | 83.4 ± 19.0 | p = 0.25 | 83.8 ± 17.7 | p = 0.39 | 84.0 ± 17.6 | p = 0.68 |
| FVC% predicted | 97.5 ± 11.5 | 98.2 ± 11.7 | p = 0.2 | 98.0 ± 11.5 | p = 0.25 | 97.0 ± 12.4 | p = 0.25 |
| Post-bronchodilator FEV1/FVC | 0.8 ± 0.1 | 0.8 ± 0.5 | p = 0.16 | 0.8 ± 0.1 | p = 0.58 | 1.0 ± 0.1 | p < 0.001 |
| SGRQ score | 14.8 ± 16.7 | 12.8 ± 15.3 | p = 0.01 | 14.2 ± 16.3 | p = 0.36 | 22.9 ± 17.1 | p < 0.001 |
| 6MWD (m) | 469.6 ± 106.5 | 448.9+-120.7 | p < 0.001 | 474.8 ± 110.2 | p = 0.23 | 438.3 ± 90.2 | p < 0.001 |
| Smoking pack-years | 37.1 ± 20.3 | 38.1 ± 20.3 | p = 0.25 | 36.5 ± 19.4 | p = 0.51 | 44.0 ± 27.8 | p < 0.001 |
| Inspiratory CT volume (mL) | 5318.8 ± 1237.7 | 5273.9 ± 1261.7 | p = 0.41 | 5325.2 ± 1251.6 | p = 0.90 | 5226.4 ± 1253.5 | p = 0.18 |
| Expiratory CT volume (mL) | 2639.3 ± 649.8 | 2600.3 ± 621.2 | p = 0.17 | 2597.6 ± 652.4 | p = 0.11 | 2685.6 ± 684.1 | p = 0.2 |
| TBV (mL) | 172.9 ± 38.9 | 169.3 ± 35.8 | p = 0.03 | 175.7 ± 40.6 | p = 0.08 | 171.0 ± 35.7 | p = 0.35 |
| tBV5 (%) | 77.8 ± 4.0 | 79.9 ± 4.1 | p < 0.001 | 77.8 ± 4.1 | p = 0.74 | 79.4 ± 3.3 | p < 0.001 |
| trabecular.T12 (HU) | 162.7 ± 50.5 | 143.9 ± 41.8 | p < 0.001 | 162.9 ± 48.7 | p = 0.95 | 151.4 ± 49.8 | p < 0.001 |
| cortical.T12 (HU) | 332.7 ± 57.2 | 316.4 ± 55.8 | p < 0.001 | 333.6 ± 54.2 | p = 0.69 | 320.1 ± 54.8 | p < 0.001 |
*The z-proportions test was used to compute p-values for binary variables. The unpaired t-test was used to compute p-values for continuous data. Bolded text indicates a p-value < 0.05. Abbreviations: SGRQ, St. George’s Respiratory Questionnaire; 6MWD, 6-min walk distance; TBV, total blood vessel volume; tBV5, ratio of vascular tree length in vessels with a cross-sectional area less than 5 mm2 to total vascular tree volume; trabecular.T12, average Hounsfield unit (HU) value within the trabecular region of the T12 vertebral body; cortical.T12, average Hounsfield unit (HU) value within the cortical region of the T12 vertebral body.