TABLE 2.
Summary statistics for COPDGene Phase 1, COPDGene Phase 2, and SPIROMICS cohorts for GOLD 1–2 subjects.
| COPDGene P1 | COPDGene P2 | p-value COPDGene P2 vs. COPDGene P1 | COPDGene P3 | p-value COPDGene P3 vs. COPDGene P1 | SPIROMICS | p-value SPIROMICS vs. COPDGene P1 | |
|---|---|---|---|---|---|---|---|
| GOLD 1–2 totals | 1,523 | 425 | 511 | 500 | |||
| Rapid decline (>1.5% FEV1%pred) | 29.8% | 38.4% | *p = 0.49 | 25.2% | *p = 0.72 | 24.8% | *p = 0.72 |
| Male | 46.9% | 43.8% | *p = 0.54 | 45.2% | *p = 0.6 | 41.6% | *p = 0.63 |
| White | 81.0% | 80.9% | *p = 0.68 | 81.2% | *p = 0.73 | 70.0% | *p = 0.56 |
| Current smokers | 44.5% | 34.4% | *p = 0.64 | 41.5% | *p = 0.62 | 36.6% | *p = 0.67 |
| Lower lobe PRMfSAD > 10% | 59.8% | 60.5% | *p = 0.45 | 55.6% | *p = 0.57 | 52.6% | *p = 0.59 |
| Upper lobe PRMemphysema > 2% | 55.7% | 55.8% | *p = 0.47 | 57.5% | *p = 0.53 | 52.8% | *p = 0.57 |
| Age (years) | 63.0 ± 8.5 | 67.8 ± 8.1 | p < 0.001 | 62.5 ± 8.1 | p = 0.23 | 65.6 ± 7.6 | p < 0.001 |
| Height (cm) | 170.1 ± 9.7 | 170.3 ± 9.8 | p = 0.68 | 170.6 ± 9.5 | p = 0.31 | 170.8 ± 9.3 | p = 0.15 |
| Weight (kg) | 82.3 ± 18.2 | 81.6 ± 18.3 | p = 0.45 | 81.6 ± 17.8 | p = 0.41 | 82.0 + 17.7 | p = 0.70 |
| FVC% predicted | 72.8 ± 14.3 | 74.4 ± 15.8 | p = 0.05 | 75.0 ± 15.4 | p < 0.001 | 75.2 ± 14.8 | p < 0.001 |
| Post-bronchodilator FEV1/FVC | 0.6 ± 0.1 | 0.6 ± 0.1 | p = 0.79 | 0.6 ± 0.08 | p = 0.84 | 0.8 ± 0.1 | p < 0.001 |
| SGRQ score | 26.1 ± 20.7 | 23.0 ± 19.0 | p = 0.01 | 23.4 ± 19.9 | p = 0.01 | 29.9 ± 16.5 | p < 0.001 |
| 6MWD (m) | 431.2 ± 109.4 | 424.1 ± 115.2 | p = 0.24 | 449.4 ± 105.5 | p < 0.001 | 421.9 ± 98.3 | p = 0.09 |
| Smoking pack-years | 49.1 ± 25.1 | 49.5 ± 23.7 | p = 0.75 | 47.7 ± 23.0 | p = 0.27 | 51.4 ± 25.3 | p = 0.08 |
| Inspiratory CT volume (mL) | 5788.4 ± 1384.2 | 5878.2 ± 1438.3 | p = 0.24 | 5890.9 ± 1432.1 | p = 0.15 | 5896.5 ± 1418.4 | p = 0.13 |
| Expiratory CT volume (mL) | 3312.9 ± 860.5 | 3311.7 ± 842.0 | p = 0.98 | 3278.6 ± 856.8 | p = 0.44 | 3425.1 ± 886.1 | p = 0.01 |
| TBV (mL) | 179.0 ± 39.5 | 176.3 ± 37.8 | p = 0.21 | 180.4 ± 38.8 | p = 0.50 | 182.6 ± 38.0 | p = 0.08 |
| tBV5 (%) | 78.2 ± 4.2 | 79.9 ± 3.9 | p < 0.001 | 78.1 ± 4.3 | p = 0.49 | 78.0 ± 3.4 | p < 0.001 |
| trabecular.T12 (HU) | 141.4 ± 71.0 | 133.3 ± 44.6 | p = 0.03 | 143.2 ± 47.6 | p = 0.59 | 133.6 ± 42.1 | p = 0.02 |
| cortical.T12 (HU) | 319.5 ± 62.4 | 312.5 ± 59.3 | p = 0.04 | 320.3 ± 57.1 | p = 0.8 | 313.5 ± 59.8 | p = 0.06 |
*The z-proportions test was used to compute p-values for binary variables. The unpaired t-test was used to compute p-values for continuous data. Bolded text indicates a p-value < 0.05. Abbreviations: SGRQ, St. George’s Respiratory Questionnaire; 6MWD, 6-min walk distance; TBV, total blood vessel volume; tBV5, ratio of vascular tree length in vessels with a cross-sectional area less than 5 mm2 to total vascular tree volume; trabecular.T12, average Hounsfield unit (HU) value within the trabecular region of the T12 vertebral body; cortical.T12, average Hounsfield unit (HU) value within the cortical region of the T12 vertebral body.