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. 2023 May 5;21:302. doi: 10.1186/s12967-023-04120-8

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — DVL3 overexpression was positively associated with poor prognosis in CRC patients. A–D Data from the UALCAN database showed that DVL3 was elevated in CRC tissues compared to normal controls. E The result of western blotting revealed that DVL3 expression was stronger in HT-29, HCT-8, SW480, SW620 and HCT116 cells than that in FHC cells. F DVL3 was upregulated in N1 and N2 stage of CRC nodal metastasis compared to N0 stage in data from the UALCAN database. G CRC patients with high DVL3 expression presented shorter overall survival (OS), H, I disease free Survival (DFS), J disease-specific survival (DSS) than patients with Low DVL3 expression, based on data from PrognoScan database. *P ≤ 0.05